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https://www.sciencedirect.com/science/article/pii/S1319016414000590
As discussed in the review, nanotechnology offers various efficient carriers for the delivery of proteins such as solid lipid nanoparticles, nanostructured lipid carrier, liposomes, niosomes, cubosomes and nanoparticles, etc. Various efficient approaches were discussed for formulation development of oral delivery of therapeutic proteins and it ...Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.sciencedirect.com/science/article/pii/S2211383518307305
Although a considerable number of formulated multifunctional delivery systems have shown the potential for oral delivery of therapeutic proteins/peptides, further issues concerning the safety and side effect, EE and LC of drug loaded carriers, typicality of in vitro models, reproducibility of fabrication technique, feasibility of storage ...Author: Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, Wei Huang, Mingji Jin, Qiming Wang, You Han Bae
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Keywords: Therapeutic proteins and peptides, oral delivery, formulation vehicles, absorption enhancers, enzyme inhibitors, mucoadhesive polymeric system Due to rapid progress in biotechnology, as well as gene technology, the industry is capable of producing a large number of potential therapeutic peptides and proteins in commercial quantities.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908063/
Jun 16, 2014 · 4. Clinical application of oral proteins and peptides. Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.tandfonline.com/doi/abs/10.3109/10717544.2013.819611
Jul 17, 2018 · AbstractAdvent of recombinant technology in protein synthesis has given birth to a new range of biopharmaceuticals. These therapeutic peptides and proteins are now emerging as an imperative part of various treatment protocols especially in the cancer therapeutics. Despite extensive research efforts, oral delivery of therapeutic peptide or protein is still a challenge for pharmaceutical ...Author: Sonal Gupta, Arushi Jain, Mainak Chakraborty, Jasjeet K Sahni, Javed Ali, Shweta Dang
https://researchers.dellmed.utexas.edu/en/publications/ph-responsive-polymeric-nanoparticles-for-the-oral-delivery-of-hi
Oldenkamp, HF, Koetting, MC & Peppas, N 2019, Ph-responsive polymeric nanoparticles for the oral delivery of high isoelectric point therapeutic proteins. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - …Author: Heidi F. Oldenkamp, Michael C. Koetting, Nicholas Peppas
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
Figure 1: Table summarising selected oral peptide delivery technologies. MERRION’S GIPET ® TECHNOLOGY. Merrion Pharmaceuticals (Dublin, Ireland) is developing the GIPET® technology using an enteric coating (similar to Peptelligence ® and TPE technologies), in order to protect the peptide in the acidic gastric medium and ensure peptide release in the small intestine.
https://otd.harvard.edu/explore-innovation/technologies/oral-delivery-of-biologics
Oral delivery of biologics. Biologics are used to treat a variety of chronic diseases including diabetes and arthritis. Not surprisingly, they command a large share of the therapeutics market. Moreover, a large number of therapeutic proteins are currently in clinical development and the net present value of major biologics in the pipeline is ...
https://www.researchgate.net/publication/8531815_Hydrogels_for_oral_delivery_of_therapeutic_proteins
In recent years there has been significant new interest in the development of transmucosal (mostly oral) pharmaceutical formulations for the delivery of therapeutic proteins.
https://www.researchgate.net/publication/261947231_Peptide-enhanced_oral_delivery_of_therapeutic_peptides_and_proteins
Systemic therapy upon oral delivery of biologics, such as peptide and protein drugs is limited due to their large molecular size, their low enzymatic stability and their inability to cross the ...
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