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https://www.ncbi.nlm.nih.gov/pubmed/19530907
Oral delivery of siRNA and antisense oligonucleotides. Akhtar S(1). ... (RNAi) mediated gene silencing by small interfering RNA (siRNA) has tremendous potential to silence the expression of disease-causing genes in the clinic. A major hurdle to their widespread clinical use is the safe and efficient delivery to target cells in vivo. Delivery ...Author: Saghir Akhtar
https://medicalxpress.com/news/2009-04-oral-delivery-rnai-therapeutics.html
Apr 29, 2009 · "We are very encouraged by these results, which show that oral delivery of a therapeutic dose of small, interfering RNA (siRNA) to a specific cell type in an animal model is possible, and that ...
https://www.ncbi.nlm.nih.gov/pubmed/29782023
May 04, 2018 · Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects. Ghosh SKB(1), Hunter WB(2), Park AL(1), Gundersen-Rindal DE(3). Author information: (1)Invasive Insect Biocontrol and Behavior Laboratory, Agricultural Research Service, United States Department of Agriculture.Author: Saikat Kumar B. Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen-Rindal
https://www.alnylam.com/2019/06/21/new-rnai-platform-advances-including-oral-route-of-administration-and-cns-and-ocular-delivery/
Jun 21, 2019 · We presented new advances in our RNAi therapeutics platform, including preclinical results demonstrating oral delivery of GalNAc-conjugated small interfering RNAs (siRNAs) directed to a liver target. The results were presented at the 3rd International Conference on the Long and the Short of Non-Coding RNAs, held...
https://www.frontiersin.org/articles/10.3389/fphys.2017.00256/full
Apr 28, 2017 · Keywords: insect pest, oral dsRNA delivery, gut nucleases, PTD-DRBD, dsRNA protection, RNA interference (RNAi) Citation: Gillet F-X, Garcia RA, Macedo LLP, Albuquerque EVS, Silva MCM and Grossi-de-Sa MF (2017) Investigating Engineered Ribonucleoprotein Particles to Improve Oral RNAi Delivery in Crop Insect Pests. Front.Author: François-Xavier Gillet, Rayssa A. Garcia, Leonardo L. P. Macedo, Erika V. S. Albuquerque, Maria C. M...
https://www.sciencedirect.com/science/article/pii/S0168365912005378
Oral delivery of siRNA was first reported in 2009 by Aouadi and associates in β1,3-d-glucan-encapsulated siRNA particles (GeRPs). The outer β1,3-d-glucan shell was purified from baker's yeast with base and solvent extractions followed by hydrolysis of the outer cell wall and cell contents.Author: Diane C. Forbes, Nicholas A. Peppas
https://www.jove.com/video/57390/double-stranded-rna-oral-delivery-methods-to-induce-rna-interference
Several methods have been summarized for dsRNA delivery to insects and insect cells including feeding 13, 22, soaking 73, 74, microinjection 75, and other techniques 76 used for dsRNA uptake to induce systemic RNAi. Newer methods for oral delivery of dsRNA to induce RNAi in other insects by ingestion on treated non-transgenic plants also have ...Author: Saikat Kumar B. Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen-Rindal
https://www.sciencedaily.com/releases/2009/04/090429132236.htm
May 05, 2009 · Oral Delivery System For RNAi Therapeutics Date: May 5, 2009 Source: University of Massachusetts Medical School Summary: Researchers have developed a …
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-017-0328-7
Feb 09, 2017 · We showed that oral delivery of bacterially expressed dsRNA would lead to RNAi effects in the recipient insect. Quantitative real-time PCR results showed that expression level of target MseChi1 and MseChi2 genes in gut tissue of M. separata were down-regulated after oral delivery of engineered bacteria expressing the corresponding dsRNA.Author: Oyunchuluun Ganbaatar, Budao Cao, Yanan Zhang, Duran Bao, Wenhua Bao, Hada Wuriyanghan
https://academic.oup.com/jee/article/112/1/434/5227427
Dec 03, 2018 · While injection of the dsRNA directly into the target insect hemocoel is likely the most efficient dsRNA delivery method to investigate phenotypic effects, it is not practical for the development of an RNAi-based control method. Oral administration of dsRNA (ingestion) would be more feasible; however, the target dsRNA must survive in the midgut ...Author: Man-Yeon Choi, Robert K Vander Meer
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