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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
Review Article Nanoparticles: Oral Delivery for Protein and Peptide Drugs Shu-jun Cao,1 Shuo Xu,2 Hui-ming Wang,3 Yong Ling,3 Jiahua Dong,3 Rui-dong Xia,1 and Xiang-hong Sun3,4 Received 6 October 2018; accepted 31 January 2019; published online 20 May 2019Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
formulated protein or peptide drugs may be administered by the oral route with retention of sufficient biological activity for their therapeutic use. Strategies for oral delivery Formulating for delivery through the gastrointestinal (GI) tract requires a multitude of strategies. The …File Size: 228KB
https://link.springer.com/article/10.1208/s12249-019-1325-z
May 20, 2019 · Although the oral route is a very hostile environment for peptide and protein drugs, most of the nanoparticle delivery system can help overcome many of the barriers encountered in following oral administration including enzymatic degradation and poor membrane permeability (11,19). There are some specific tissues related to immunity in the ...Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Barriers to oral delivery. Oral delivery is the preferred route of drug administration, as the majority of patients see it as the most convenient way to take their drugs [].Drugs taken by the oral route have the highest level of patient compliance due to the ease and simplicity of taking medications [11,12].Despite the large number of protein therapeutics being discovered each year, oral ...Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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