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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · However, oral delivery of insulin has some limitations, which include low bioavailability due to insulin degradation in the gastrointestinal tract (GIT) by proteolytic enzymes and severe pH physiological conditions as well as poor permeability through the intestinal epithelium. 11 Notwithstanding, the oral route is back in the forefront as an alternative route of insulin …Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/oral-insulin-delivery/
Insulin, from the pancreas or from oral delivery, reaches the liver in high concentrations (3 times more than other tissues), activating the liver to participate in blood sugar control and regulate a number of metabolic activities that can help mitigate complications of diabetes.
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin.
https://www.outsourcing-pharma.com/Article/2019/10/15/Novo-Nordisk-and-MIT-on-oral-delivery-of-insulin
Oct 15, 2019 · The design of the capsule enables the delivery of a comparable amount of insulin to that of an injection, as well as to protect the drug substance from breaking down due to the harsh environment of the gastrointestinal tract.
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/oral-delivery-of-insulin-novel-approaches
The naturally-occurring polymers of particular interest in the oral delivery of insulin are either polysaccharides or else proteins. Polysaccharides include chitosan, hyaluronan, dextran, cellulose, pullulan, chondroitin sulphate and alginate. Meanwhile, the protencious polymers are …Author: Amani M. Elsayed
https://www.webmd.com/diabetes/features/insulin-delivery
This device is about the size of a pager. You wear it on your belt or in a pocket. It delivers a steady stream of insulin to your body 24 hours a day through a needle attached to a flexible plastic tube. Whenever you eat, you press a button on the pump to give yourself an extra boost of insulin…
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