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https://www.sciencedirect.com/science/article/pii/S2095927316301281
Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. ... followed by delineating how rational design takes the advantage of physiopathological changes to achieve colon-specific targeting and drug release. We conclude with a discussion of challenges and opportunities in developing next-generation colon ...Author: Lei Lu, Gaoxian Chen, Yuanyuan Qiu, Mingwang Li, Dianhua Liu, Dehui Hu, Xiajing Gu, Zeyu Xiao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · The development of colon-targeted oral drug delivery systems has gained increasing interest among formulation scientists in recent years. As discussed above, colon-specific drug delivery systems provide significant therapeutic benefits to the patients in terms of …Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches. ... Design of enteric coated timed-release press coated tablet (ETP Tablet) ... It has therefore been concluded that drug dissolution in the colon could present a problem in relation to colon-specific oral drug delivery systems.Author: Anil K. Philip, Betty Philip
https://www.researchgate.net/publication/288637667_Oral_colon-specific_drug_delivery
Colon-specific drug delivery systems offer several potential therapeutic advantages. In a number of colonic diseases such as colorectal cancer, Crohn's disease and spastic colon, it has been shown ...
https://www.researchgate.net/publication/232040952_Oral_colon-specific_drug_delivery_A_review
The most critical challenge in oral colon specific drug delivery approach is to preserve the formulation during its passage through the stomach and about first six meters of the small intestine.
https://www.sciencedirect.com/science/article/pii/S1549963415000684
Current oral nano-delivery system strategies for drug delivery to inflamed colon. Improved oral drug delivery design has drastically improved the colonic bioavailability of drugs, that is, these formulations are effective at reaching and releasing drug specifically in the colon.Author: Susan Hua, Ellen Marks, Jennifer J. Schneider, Simon Keely
http://www.eurekaselect.com/113069/article
This review mainly compares different strategies for colon specific drug delivery such as prodrug and polymeric prodrug, which achieved limited success and have limitations as compared with novel colon specific drug delivery systems namely pressure, time, pH and bacteria dependent, chitosan-calcium alginate microparticles, microsponges ...Author: Rashmi Sareen, Nitin Jain, K. L. Dhar
https://link.springer.com/article/10.1208%2Fs12249-015-0350-9
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://link.springer.com/content/pdf/10.1208%2Fs12249-015-0350-9.pdf
Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches Seth Amidon,1 Jack E. Brown,1 and Vivek S. Dave1,2 Received 3 February 2015; accepted 4 June 2015; published online 13 June 2015 Abstract. Colon-specific drug delivery systems (CDDS) are desirable for the treatment of …Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://rd.springer.com/article/10.1007/s11434-016-1056-4
Apr 04, 2016 · Colon-targeted oral delivery is crucial for the treatment of colon-related diseases, as this delivery strategy enables precise drug administration to the diseased site, enhances drug bioavailability, and improves patient compliance. In particular, nanoparticle-based oral formulations shield drugs from the harsh gastrointestinal environment, and selectively increase drug concentration inside ...Author: Lei Lu, Gaoxian Chen, Yuanyuan Qiu, Mingwang Li, Dianhua Liu, Dehui Hu, Xiajing Gu, Zeyu Xiao
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