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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Periocular drug delivery using the transscleral absorption pathway is one of the safest means of achieving consistent therapeutic drug concentrations in the inner coat of the posterior segment (Table 1). 5,6,24 Periocular drug delivery systems, however, require drugs to pass through several layers of ocular tissue (episclera, sclera, choroid ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
To improve ocular topical drug delivery, drug designers have developed strategies that minimize precorneal drug loss and maximize corneal drug absorption. They use three main approaches to deal ...
https://www.sciencedirect.com/science/article/pii/S1350946297000025
Ophthalmic Drug Delivery Systems Topically applied drugs reach the bloodstream mainly via absorption across the mucosa in the nasal cavity which is contiguous with the conjunctival sac (Chang and Lee, 1987). Conse- quently, delivery systems that prolong the resi- dence time of the applied dose in the conjunctival sac would be expected to reduce ...Author: Chrystèle Le Bourlais, Liliane Acar, Hosein Zia, Pierre A. Sado, Thomas Needham, Roger Leverge
https://www.slideshare.net/patelbindi/ophthalmic-drug-delivery-system
Aug 07, 2014 · Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases. Eye is the most easily accessible site for topical administration of a medication. Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time. The newest ...
https://www.ondrugdelivery.com/magazines/ophthalmic-drug-delivery-48/
ZERO-ORDER SUSTAINED DRUG DELIVERY TO THE RETINA FROM A NANOPOROUS FILM DEVICE . Daniel Bernards, Robert Bhisitkul and Tejal Desai discuss the development of a nanoporous membrane-based implant which can significantly improve drug delivery to the back of the eye. OCULAR
https://en.wikipedia.org/wiki/Ophthalmic_drug_administration
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. However, there are many challenges associated with topical delivery of drugs to the cornea of the eye.
https://www.sciencedirect.com/science/article/pii/S0168365918303791
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being explored to develop colloidal drug carriers which show better performance than the more popular drug solutions.Author: Julieta C. Imperiale, Gabriela B. Acosta, Alejandro Sosnik
https://www.ondrugdelivery.com/magazines/ophthalmic-drug-delivery-63/
Chris Muller and Deepank Utkhede introduce Mati Therapeutics' Evolute ® ocular delivery system, a non-invasive, sustained-release platform that combines a novel punctal plug with …
https://www.researchgate.net/publication/278696812_Nanotechnology_in_Ophthalmic_Drug_Delivery
The present chapter overviews the emerging role of nanotechnology in ophthalmic drug delivery with emphasis on what has been patented over the past decade. Discover the world's research.
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