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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Periocular drug delivery using the transscleral absorption pathway is one of the safest means of achieving consistent therapeutic drug concentrations in the inner coat of the posterior segment (Table 1). 5,6,24 Periocular drug delivery systems, however, require drugs to pass through several layers of ocular tissue (episclera, sclera, choroid ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.slideshare.net/patelbindi/ophthalmic-drug-delivery-system
Aug 07, 2014 · Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases. Eye is the most easily accessible site for topical administration of a medication. Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time. The newest ...
https://www.sciencedirect.com/science/article/pii/S1350946297000025
Ophthalmic Drug Delivery Systems Topically applied drugs reach the bloodstream mainly via absorption across the mucosa in the nasal cavity which is contiguous with the conjunctival sac (Chang and Lee, 1987). Conse- quently, delivery systems that prolong the resi- dence time of the applied dose in the conjunctival sac would be expected to reduce ...Author: Chrystèle Le Bourlais, Liliane Acar, Hosein Zia, Pierre A. Sado, Thomas Needham, Roger Leverge
https://www.sciencedirect.com/science/article/pii/0039625784901681
Objectives in the Development of Ophthalmic Drug Delivery Systems Most ophthalmic drugs are applied topically in the form of eyedrops. In the absence of any efforts to modify it, the time course of drug delivery from an eyedrop follows the pattern shown in Fig. 1,'s which amounts to a "pulse-entry" of the drug, followed by a rapid decline in ...Author: John W. Shell, John W. Shell
https://rgmaisyah.files.wordpress.com/2013/12/ophthalmic-drug-delivery-systems.pdf
58 Ophthalmic Drug Delivery Systems, edited byAshim K Mttra 59 Pharmaceutical Skin Penetration Enhancement, edited by Kenneth A Walters and Jonathan Hadgraft 60 Colonic Drug Absorption and Metabolism, edited by Peter R Bieck 61 Pharmaceutical Particulate Carriers Therapeutic Applications, edited by Alam Rolland
https://www.mdpi.com/1999-4923/10/1/10
The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal ...Author: Marion Dubald, Sandrine Bourgeois, Véronique Andrieu, Hatem Fessi
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
OCULAR DRUG DELIVERY SYSTEM – A REVIEW ... The first one is based on the use of sustained drug delivery systems, which provide the controlled and continuous delivery of ophthalmic drugs. The ...
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
Ocular Surgery News In understanding how much of an artificial tear or a prescription eye drop actually reaches its target tissue, it is helpful to appreciate the significant obstacles to drug ...
https://www.mdpi.com/1999-4923/10/1/10/pdf
pharmaceutics Review Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review Marion Dubald 1,2, Sandrine Bourgeois 1,3, Véronique Andrieu 4 and Hatem Fessi 1,3,* 1 Univ Lyon, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS), Laboratoire d’Automatique et de GEnie des Procédés (LAGEP) Unité Mixte de Recherche UMR 5007,Author: Marion Dubald, Sandrine Bourgeois, Véronique Andrieu, Hatem Fessi
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