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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Topical Drug Delivery. Topical instillation of ophthalmic drops is the most common method used to administer pharmaceutical agents for ocular disease; 90% of ophthalmic drug formulations are for topical drop use. Methods of topical drug delivery include eye drops, ointments, suspensions, contact lenses, and some drug delivery devices.Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
To overcome the ocular drug delivery barriers and improve ocular bioavailability, various conventional and novel drug delivery systems have been developed such as emulsion, ointments, suspensions, aqueous gels, nanomicelles, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
Understanding topical ophthalmic drug delivery: How much gets in? Several obstacles stand in the way of effective ocular drug penetration. Ocular Surgery News U.S. Edition, January 10, 2019 ...
https://www.researchgate.net/profile/Sudip_Das4/publication/279418971_Microparticles_and_Nanoparticles_in_Ocular_Drug_Delivery/links/5b8cd0e3299bf1d5a73a0ba4/Microparticles-and-Nanoparticles-in-Ocular-Drug-Delivery.pdf
ophthalmic drug delivery technique that may enhance dosage form accept- ability while providing sustained release in the ocular milieu (14). Particulate drug delivery consists of systems described ...
http://mysticpharmaceuticals.com/delivery-systems/ophthalmic-delivery-solutions/
Mystic offers patient-centric delivery systems for systemic intranasal, nose-to-brain, ophthalmic, sublingual, dermal and oral delivery. Our delivery platforms and integration services provides a custom optimized delivery system in combination with your drug or biologic to meet your technical product and market requirements.
https://lubrizolcdmo.com/blog/the-fdas-recent-uptick-in-ophthalmic-nda-bla-approvals/
Jun 11, 2019 · Ahead of the webinar, “Overcoming Challenges in Ophthalmic Drug Delivery Including Bioavailability and Sterility,” Ashley Rein, Robert Lee, and Barbara Morgan explored the driving factors behind the recent increase in ophthalmic NDA and BLA approvals. The History of FDA Approvals. For many years it was believed that the golden age of FDA new drug approvals was behind us.
https://www.sciencedirect.com/science/article/pii/S0142961208000574
A number of approaches have recently been explored to develop biocompatible and comfortable vehicles for controlled ophthalmic drug delivery. However, topical application of eye drops is still the dominant treatment methodology despite its inefficiency and possible side effects , , . When instilled as eye drops, ophthalmic drugs have a short ...Author: Jinah Kim, Anthony Conway, Anuj Chauhan
https://www.ondrugdelivery.com/magazines/ophthalmic-drug-delivery104/
OPTIMISING OPHTHALMIC DRUG DELIVERY FOR THERAPEUTIC EFFECTIVENESS . Barbara Morgan discusses how eye physiology impacts product formulation and choice of dosage form, and how advanced delivery technologies are providing new options for formulators seeking to improve the bioavailability or stability of their ophthalmic treatments.
https://www.sciencedirect.com/science/article/pii/S0168365918303791
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being explored to develop colloidal drug carriers which show better performance than the more popular drug solutions.Author: Julieta C. Imperiale, Gabriela B. Acosta, Alejandro Sosnik
https://en.wikipedia.org/wiki/Ophthalmic_drug_administration
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. However, there are many challenges associated with topical delivery of drugs to the cornea of the eye.
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