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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815777/
Feb 16, 2016 · There is also an increasing trend to demystifying oncolytic viruses and regarding them simply as a new type of drug, with appropriate consideration of their bioavailability and pharmacokinetics. Indeed, the first oncolytic virus was licensed by FDA in October 2015 to Amgen (Thousand Oaks, CA, USA) for the treatment of advanced melanoma.Author: Leonard W Seymour, Kerry D Fisher
https://www.dovepress.com/oncolytic-virus-delivery-from-nano-pharmacodynamics-to-enhanced-oncoly-peer-reviewed-fulltext-article-OV
Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect Raquel Yokoda,1 Bolni M Nagalo,1 Brent Vernon,2 Rahmi Oklu,3 Hassan Albadawi,3 Thomas T DeLeon,1 Yumei Zhou,1 Jan B Egan,1 Dan G Duda,4 Mitesh J Borad1 1Division of Hematology Oncology, Department of Medicine, Mayo Clinic, Scottsdale, 2Department of Biomedical Engineering, Arizona State University, …Author: Raquel Yokoda, Bolni M Nagalo, Brent Vernon, Rahmi Oklu, Hassan Albadawi, Thomas T DeLeon, Yumei Zho...
https://cancerimmunolres.aacrjournals.org/content/early/2020/03/03/2326-6066.CIR-19-0628
Jan 01, 2020 · Oncolytic virotherapy can lead to systemic antitumor immunity, but the therapeutic potential of oncolytic viruses (OVs) in humans is limited due to their insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). Here, we showed that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced …Author: Chaolong Lin, Wenfeng Ren, Yong Luo, Shaopeng Li, Yating Chang, Lu Li, Dan Xiong, Xiaoxuan Huang, Zi...
https://www.hindawi.com/journals/av/2012/805629/
Several agents that can enhance the systemic delivery of oncolytic viruses have been separately used or tested in clinical trials. It is conceivable that a combination strategy to enhance the systemic delivery of oncolytic viruses should and will be employed in the near future.Author: Mark S. Ferguson, Nicholas R. Lemoine, Yaohe Wang
https://www.tandfonline.com/doi/pdf/10.1080/17425247.2019.1617269
Achieving systemic delivery of oncolytic viruses Claudia Hill and Robert Carlisle Institute of Biomedical Engineering, University of Oxford, Oxford, UK ABSTRACT Introduction: Oncolytic virotherapy is a selective and powerful tool for cancer treatment. StudiesAuthor: Claudia Hill, Robert Carlisle
https://www.pegsummit.com/Oncolytic-Viral-Therapy
Oncolytic virus potency can be favorably impacted by concomitant immunosuppressive drug therapy to retard the host antiviral response and accelerate intratumoral spread. But without stringent targeting of virus tropism, increased OV potency is associated with an increased risk of off-target toxicity.
http://www.nature.com/articles/bjc2015481
Jan 14, 2016 · Systemic delivery is a major goal in the field of oncolytic viruses, allowing the agent to access disseminated tumour deposits. However, despite the compelling simplicity of a self-amplifying ...Author: Leonard W Seymour, Kerry D Fisher
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