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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664895/
Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery. Meanwhile, an effective delivery system must successfully overcome a multitude of biological barriers to enable the oligonucleotides to reach the site of action and access their biological targets.Author: Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1081&context=ps_patents
OLIGONUCLEOTIDE DELIVERY SYSTEMS FOR CAMPTOTHECINS This is a National Stage Application under 35 U.S.C. §371 of International Application No. PCT/US98/20941, ?led on Oct. 14, 1998. This invention Was made With Government support under NIH grant NIH CA: 63653. The Government may have certain rights in this invention. TECHNICAL FIELDAuthor: Thomas G. Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
https://www.researchgate.net/publication/262075546_Oligonucleotide_delivery_A_patent_review_2010-2013
Oligonucleotide delivery: A patent review (2010-2013) ... focusing on the development of safe and effective non-viral drug delivery systems for the treatment of diseases such as cancer or genetic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381599/
Traditionally, systemic delivery of oligonucleotide drugs has been performed by intravenous injection of either naked molecules or within delivery systems, but nonspecific accumulation in various tissues has favored local delivery routes such as to the lungs so as to ensure direct access to the target site.Author: Jørgen Kjems, Kenneth A Howard
https://www.sciencedirect.com/topics/neuroscience/antisense-oligonucleotide
Both of these delivery systems will then deliver the genetic material to the cell as described in the previous sections. The stability of oligonucleotides once in the cell is another limiting aspect to ASO therapy. Oligonucleotides are very sensitive to degradation by exogenous and endogenous nucleases.
https://link.springer.com/article/10.1208%2Fs12248-009-9096-1
Mar 19, 2009 · Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery. Meanwhile, an effective delivery system must successfully overcome ...Author: Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
https://www.researchgate.net/publication/24210197_Targeted_Delivery_Systems_for_Oligonucleotide_Therapeutics
Major challenges for oligonucleotide delivery in vivo . After administration into blood circulation ( 1 ), the targeted ON particles are exposed to plasma components that can degrade the ON molecules.
http://onlinelibrary.wiley.com/doi/10.1002/app.40293/full
Feb 01, 2014 · PEGylation technology is also considered promising method in the development of a gene-delivery system, including oligonucleotide delivery. In recent years, a variety of nanoparticles such as micelles and liposomes have been used for gene delivery.
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/smart-oligonucleotide-delivery.html
Despite this success in vivo, clinical trials for polymeric oligonucleotide delivery systems remain rare. The current hurdles for oligonucleotide therapeutics in clinical trials are typically rapid renal and liver clearance. 26 The stabilization of PIC micelles through chemical modifications could reduce the rate of …
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