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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786135/
Dec 16, 2011 · Gold nanoparticles (AuNPs) hold great interest in drug delivery because these materials can be functionalized with a range of biological cargos, induce minimal toxicity, and can be efficiently cleared from the body. 1 For example, many studies have described conjugation of DNA or RNA to particle surfaces in well-defined configurations, and these materials have been applied in numerous biological and therapeutic settings. 1, 2 Devising …Author: Christopher M. Jewell, Jin-Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci, Dar...
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201104514
Oligonucleotide Delivery by Cell‐Penetrating “Striped” Nanoparticles †. C.M.J. is supported by a postdoctoral fellowship from the Ragon Institute. J.M. is supported by the Korea Research Foundation Grant (KRF‐2008‐357‐D00090). D.J.I. is an investigator of the Howard Hughes Medical Institute.Author: Christopher M. Jewell, Jin-Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci, Dar...
https://www.ncbi.nlm.nih.gov/pubmed/22028047
Dec 16, 2011 · Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. Jewell CM(#)(1), Jung JM(#)(1), Atukorale PU(1), Carney RP(2), Stellacci F(2), Irvine DJ(1)(3). Author information: (1)Depts. of Materials Science and Engineering and Biological Engineering, Koch Institute for Integrative Cancer Research, Ragon Institute of MGH, MIT, and ...Author: Christopher M. Jewell, Jin-Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci, Dar...
https://www.ncbi.nlm.nih.gov/pubmed/29734750
May 05, 2018 · The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back by their low bioavailability and poor cellular uptake …Author: Graham McClorey, Subhashis Banerjee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661726/
Nov 27, 2015 · A variety of cellular delivery systems have been developed during the last few years. These include microinjection, electroporation, cotransfection with DNA, or conjugation to lipophilic moieties, nanoparticles, cell-penetrating peptides (CPPs), oligo-aspartic acid, or nuclear localization signal (NLS) peptides to enhance cellular internalization.Author: Xing-Liang Zhao, Bi-Cheng Chen, Jin-Chao Han, Lai Wei, Xiao-Ben Pan
https://www.nature.com/articles/s41598-018-29556-7
Jul 26, 2018 · The current study investigated the use of two cationic peptides, Xentry-KALA (XK) and Xentry-Protamine (XP), for intracellular delivery of Connexin43 antisense oligonucleotides (Cx43AsODN).Author: Frazer P. Coutinho, Colin R. Green, Ilva D. Rupenthal
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30509-3
Among these, the cell-penetrating peptides (CPPs) have gained quickly broadening popularity as promising nonviral transmembrane delivery vectors. Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery: Molecular TherapyAuthor: Helerin Margus, Kärt Padari, Margus Pooga
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130259/
Cationic liposomes have been routinely used as delivery vectors for ONs; however, toxicity remains a significant problem, according to several in vivo findings . One class of vectors that appears potent for this purpose without the associated toxicity of cationic liposomes is cell-penetrating peptides (CPPs).Author: Kariem Ezzat, Samir El Andaloussi, Eman M. Zaghloul, Taavi Lehto, Staffan Lindberg, Pedro M. D. More...
https://www.sciencedirect.com/science/article/pii/S1471489206001251
Oligonucleotide delivery. Efficient delivery of ONs such as small interfering RNAs (siRNAs), decoy-ONs and plasmids, and their analogues such as peptide nucleic acids (PNAs), locked nucleic acids (LNAs) and phosphorodiamidate morpholino oligomers (PMOs), are desired for controlling gene expression or for silencing the activity of certain proteins.Author: Maarja Mäe, Ülo Langel
https://www.researchgate.net/publication/262075546_Oligonucleotide_delivery_A_patent_review_2010-2013
Oligonucleotide delivery: A patent review (2010-2013) ... a wide group of peptides called cell-penetrating peptides (CPPs) have been considered one of the most promising tools to improve non ...
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