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https://www.sciencedirect.com/science/article/pii/S0168365911006791
The absorption band at 1640 cm –1, assigned to primary amines of chitosan, significantly diminished for 9R-modified chitosan. In addition, a peak for the amide bond at 1550 cm –1 was clearly observed for 9R-modified chitosan, indicating successful linkage between oligoarginine and chitosan.Author: Soyeon Park, Sang Kyung Lee, Kuen Yong Lee
https://www.researchgate.net/publication/51985258_Oligoarginine-modified_chitosan_for_siRNA_delivery
Oligoarginine-modified chitosan for siRNA delivery Article in Journal of Controlled Release 152 Suppl 1:e165-6 · November 2011 with 8 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0144861712009083
In the present study, we demonstrated that oligoarginine-modified chitosan/siRNA nanoparticles are useful for delivering siRNA in vitro. Oligoarginine-modified chitosan was synthesized by chemical conjugation of nonaarginine to the chitosan backbone and used to prepare nanoparticles by charge complex formation with siRNA.Author: Soyeon Park, Eun Ju Jeong, Jangwook Lee, Taiyoun Rhim, Sang Kyung Lee, Kuen Yong Lee
https://www.researchgate.net/publication/233876376_Preparation_and_characterization_of_nonaarginine-modified_chitosan_nanoparticles_for_siRNA_delivery
It is possible to overcome this obstacle by adding to the siRNA, oligoarginine-modified chitosan that improves the siRNA delivery into cells with low toxicity [156]. TAT peptide can also be used ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691089/
Dec 04, 2015 · Recently, chitosan-based delivery systems have received increasing attention as a safe carrier for genetic material including, plasmid DNA (pDNA) and small interfering RNA (siRNA). Chitosan is a straight chain natural polysaccharide composed of randomly distributed β-(1→4)-linked d-glucosamine and N-acetyl-d-glucosamine .Author: Buddhadev Layek, Lindsey Lipp, Jagdish Singh
https://ui.adsabs.harvard.edu/abs/2015Nanos...720095J/abstract
Nov 01, 2015 · Chitosan derivatives modified with oligoarginine containing a spacer arm can be considered as potential delivery vehicles for various genes.Although chitosan and its derivatives have been frequently utilized as delivery vehicles for small interfering RNA (siRNA), it is challenging to improve the gene silencing efficiency of chitosan-based ...Author: Eun Ju Jeong, Moonhwan Choi, Jangwook Lee, Taiyoun Rhim, Kuen Yong Lee
https://www.deepdyve.com/lp/elsevier/preparation-and-characterization-of-nonaarginine-modified-chitosan-bw3OTekF3y
Jan 30, 2013 · Read "Preparation and characterization of nonaarginine-modified chitosan nanoparticles for siRNA delivery, Carbohydrate Polymers" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666663/
Recently, cell-penetrating peptides have been proposed to translocate antibodies, proteins, and other molecules in targeted drug delivery. The proposed study presents the synthesis and characterization of a peptide-based chitosan nanoparticle for small interfering RNA (siRNA) delivery, in-vitro.Author: Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Imen Kahouli, Satya Prakash
https://pubs.rsc.org/en/content/articlelanding/2015/nr/c5nr06903c
Although chitosan and its derivatives have been frequently utilized as delivery vehicles for small interfering RNA (siRNA), it is challenging to improve the gene silencing efficiency of chitosan-based nanoparticles. In this study, we hypothesized that controlling …Author: Eun Ju Jeong, Moonhwan Choi, Jangwook Lee, Taiyoun Rhim, Kuen Yong Lee
https://pubs.acs.org/doi/10.1021/acs.biomac.7b01297
Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery but with contradictory findings for incompletely characterized systems. For understanding which parameters produce effective delivery, a library of precisely characterized chitosans was produced at different degrees of deacetylation (DDAs) and average molecular weights (Mn).Author: Mohamad Gabriel Alameh, Marc Lavertu, Nicolas Tran-Khanh, Chi-Yuan Chang, Frédéric Lesage, Martine B...
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