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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nucleic-acid-delivery
Virginie Busignies, ... Virginie Escriou, in Nanostructures for Oral Medicine, 2017. 4 Conclusions. Increasing nucleic acid delivery systems are developed for the oral route. Although therapeutic nucleic acids molecules exhibit unique properties in terms of stability and characteristics like global charge and size, an effective delivery through oral administration has been demonstrated in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701888/
Oral delivery of nucleic acid-based therapeutics has tremendous potential in treating numerous human diseases, as long as safe and effective target site delivery is possible. Encapsulation of nucleic acids within multi-compartmental systems has been utilized for enabling local gene or siRNA delivery in the intestine after oral delivery.Author: Husain Attarwala, Murui Han, Jonghan Kim, Mansoor Amiji, Mansoor Amiji
https://www.researchgate.net/publication/227203189_Oral_Delivery_of_Nucleic_Acid_Drugs
The successful development of oral nucleic acid delivery systems is challenged by a variety of barriers encountered with the GI tract. The intestinal mucosa is both a physical and a biochemical ...Author: Ronny Martien
https://www.sciencedirect.com/science/article/pii/S0928098719301368
The future trends for the oral delivery of nucleic acid-based therapeutics will rely on the future developments in molecular biology and new knowledges in disease physiopathology to identify new targets for gene therapy e.g. the identification of new genes involved in IBD.Author: Caitriona M. O'Driscoll, Andreas Bernkop-Schnürch, Julian D. Friedl, Véronique Préat, Vincent Jannin
https://www.ncbi.nlm.nih.gov/pubmed/28544521
Oral route of drug administration has greater delivery challenges, because the administered genes or oligonucleotides have to bypass degrading environment of the gastrointestinal (GI) tract in addition to overcoming other cellular barriers preventing nucleic acid delivery. For efficient oral nucleic acid delivery, vector should be such that it ...Author: Husain Attarwala, Murui Han, Jonghan Kim, Mansoor Amiji, Mansoor Amiji
http://engconf.us/conferences/biotechnology-2/delivery-of-nucleic-acid-therapeutics-ii-biology-engineering-and-development/
The ECI “Delivery of Nucleic Acid Therapeutics: Biology, Engineering and Development” conference will provide a forum for increasing our mechanistic understanding of the biological processes underpinning non- viral and viral NAT delivery, including molecular and cellular biology, virology, in vivo pharmacology and toxicology, rational ...
https://www.future-science.com/doi/pdfplus/10.4155/tde.11.143
Oral delivery of nucleic acid-based therapeutics Editorial future science group www.future-science.com 145 The next question may well be, ‘Is there a better formulation, one which achieves a higher
https://www.researchgate.net/publication/316344364_Nanostructures_for_oral_delivery_of_therapeutic_nucleic_acids
Current nucleic acid–based treatment strategies are largely injection-based, but effective oral delivery platforms for nucleic acids may result in improved patient comfort and compliance.
http://www.pnabio.com/peptide-nucleic-acid
About PNA. PNA (Peptide Nucleic Acid) is an artificially synthesized polymer similar to DNA or RNA. The various purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds as …
https://www.businesswire.com/news/home/20181002005233/en/Exicure-Presents-Data-Demonstrating-Oral-Delivery-Liver
“ On behalf of the Exicure team, we are pleased to present the first data highlighting oral delivery of our spherical nucleic acid technology,” said Dr. David Giljohann, Chief Executive ...
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