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https://pubs.acs.org/doi/abs/10.1021/ja211035w
However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time.Author: Limin Pan, Qianjun He, Jianan Liu, Yu Chen, Ming Ma, Linlin Zhang, Jianlin Shi
https://www.sciencedirect.com/science/article/pii/S0753332219319924
Nuclear-targeted nanoparticle drug delivery system, which enables intranuclear release of anticancer drugs, is expected to address this challenge. In this study, based on nucleolin’s active transport property to the nucleus and its affinity with aptamer, we developed a nuclear-targeted delivery system to circumvention of drug resistance in breast cancer (MCF-7/Adr).Author: Xin Li, Xiuhua Wu, Hongyu Yang, Lin Li, Ziqi Ye, Yuefeng Rao
https://pubs.acs.org/doi/10.1021/bc400170r
We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent ...Author: Avijit Jana, Biswajit Saha, Deb Ranjan Banerjee, Sudip Kumar Ghosh, Kim Truc Nguyen, Xing Ma, Qiuyu ...
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/nuclear-medicine-and-drug-delivery
Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. The use of nuclear medicine and radiopharmaceuticals allows studying the in vivo behavior of developed drug‐delivery systems,...Author: Ana Rita Fernandes, Ana Oliveira, Jorge Pereira, Pedro Silva Coelho
https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.201800032
Mar 11, 2018 · Targeted drug delivery has been widely explored for efficient tumor therapy with desired efficacy but minimized side effects. It is widely known that large numbers of DNA‐toxins, such as doxorubicin, genes, reactive oxygen species, serving as therapeutic agents, can result in maximized therapeutic effects via the interaction directly with DNA helix.Author: Limin Pan, Jianlin Shi
http://www.skl.sic.cas.cn/yjly/swyy/sjl/zl/200809/W020120427557580210573.pdf
have been developed to target cancer cells but rarely nuclei. However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047275/
Feb 26, 2020 · 2. Size Impact on Delivery Efficacy. As one of the most important characteristics of nanoparticles, size greatly influences the efficiency of tumor targeted drug delivery in many ways, including circulation, biodistribution, tumor accumulation and penetration, as well as cellular uptake and subcellular distribution.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · Targeted drug delivery refers to predominant drug accumulation within a target zone that is independent of the method and route of drug administration . On the other hand, targeted therapy or targeted medicine means specific interaction between a drug …Author: You Han Bae, Kinam Park
https://www.sciencedirect.com/science/article/pii/S0142961212006850
Nuclear-targeted therapy by delivering anticancer drug directly into cancer cell nuclei can elicit synergistic therapeutic effects and kill these cancer cells with much enhanced efficiencies. Besides nuclear targeting, another difficulty in nuclear-targeted therapy is how to achieve real-time monitoring of the therapy process simultaneously.Author: Jia Nan Liu, Wenbo Bu, Li Min Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuai Le Zhao, Weijun ...
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.
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