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https://www.sciencedirect.com/science/article/abs/pii/S0168365911005682
A large number of anticancer drugs are DNA-toxins that bind nuclear DNA or its associated enzymes to exert their cytotoxicity to cancer cells. After entering tumor cells, they need to be further delivered to the nucleus for actions.
https://www.sciencedirect.com/science/article/pii/S0168365911005682
Subsequently there are two pathways for nuclear drug delivery: (1) Indirect nuclear drug delivery — cytosol-targeted drug delivery followed by nuclear accumulation; that is, either the carried drug is released from the nanocarrier into the endo/lysosome and then into the cytosol, or the nanocarrier escapes from the endo/lysosome into the cytosol and slowly releases the drug.Author: Meihua Sui, Wenwen Liu, Youqing Shen
https://www.ncbi.nlm.nih.gov/pubmed/21846484
Oct 30, 2011 · A large number of anticancer drugs are DNA-toxins that bind nuclear DNA or its associated enzymes to exert their cytotoxicity to cancer cells. After entering tumor cells, they need to be further delivered to the nucleus for actions.Author: Meihua Sui, Wenwen Liu, Youqing Shen
https://www.researchgate.net/publication/51575928_Nuclear_drug_delivery_for_cancer_chemotherapy
Herein, we discuss the biological barriers and summarize recent progress of nuclear drug delivery for cancer chemotherapy, emphasizing strategies that appear useful for design of vehicles capable ...
https://www.researchgate.net/publication/235167299_Nuclear_Drug_Delivery_for_Breast_Cancer_Chemotherapy
Chemo-resistant breast cancer cells overexpress not only membrane-associated but also many cytosolic drug-resistance mechanisms to limit the access of DNA-toxins to the nucleus, causing low ...
http://grantome.com/grant/NSF/CBET-0753109
Drugs delivered by these cancer nuclear-targeted carriers had much high efficiency in killing cancer cells. Thus, the nuclear drug delivery developed in this project is a new drug delivery approach to effectively overcoming cancer drug resistance, a major cause of cancer treatment failure, and provides a new and effective therapy for clinical treatment of cancer.
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Recently, multifunctional QDs have been synthesized, making them a promising targeted drug delivery vehicle for the diagnosis and image-guided chemotherapy of various cancers 25, 26.Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://medicalxpress.com/news/2012-04-cancer-drug-delivery.html
Apr 04, 2012 · The nanomedicine was combined with the chemotherapy drug docetaxel (Taxotere), often used against solid tumors found in patients with breast, ovarian, prostate and non-small cell lung cancer…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134022/
Aug 08, 2014 · Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal.Author: Giovana Calixto, Jéssica Bernegossi, Bruno Fonseca-Santos, Marlus Chorilli
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