We have collected information about Novel Oral-Based Drug-Delivery Technology For Biologically Active Peptides And Proteins for you. Follow the links to find out details on Novel Oral-Based Drug-Delivery Technology For Biologically Active Peptides And Proteins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
As the GI-MAPS is a novel drug-delivery system preparation, the fabrication method is the second hurdle to overcome in the launch of an oral preparation of proteins. However, recent advances in microfabrication technology in the semiconductor industry have made it possible to produce many micron-size GI-MAPS.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
Delivering therapeutically active protein and peptides by the oral route has been a challenge and a goal for many decades. The oral route is unsuitable for the systemic delivery of therapeutic peptides and proteins because of the potential degradation by the strongly acid environment in the stomach and by the proteolytic enzymes in the ...
https://www.sciencedirect.com/science/article/pii/S1359644606003084
Administering drugs orally is by far the most widely used route of administration, although it is generally not feasible for peptide and protein drugs. The main reasons for the low oral bioavailability of biologicals are presystemic enzymatic degradation and poor penetration of the intestinal membrane 4, 5.Author: Mariko Morishita, Nicholas A. Peppas
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The current article deals with the possibilities being explored in the oral delivery of protein and peptide therapeutics, the challenges in their development and the current and future prospects, with focus on technology trends in the market to improve the bioavailability of proteins and peptides and effect of different forms of therapeutic ...Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.researchgate.net/publication/268424510_Oral_Peptide_and_Protein_Drug_Delivery
Oral Peptide and Protein Drug Delivery. Recent advances in biotechnology and biochemistry have profoundly led to the discovery of numerous biologically active peptides and proteins. Their therapeutic applications have also been extensively investigated. Oral administration has major advantages on patient compliance and low cost of production.
https://www.nature.com/articles/nbt1201-1173
Dec 01, 2001 · This peptide carrier is able to efficiently deliver a variety of peptides and proteins into several cell lines in a fully biologically active form, without the need for prior chemical covalent ...Author: May C. Morris, Julien Depollier, Jean Mery, Frederic Heitz, Gilles Divita
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492185/
Apr 22, 2015 · Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers …Author: Samira Jafari, Solmaz Maleki Dizaj, Khosro Adibkia
https://www.researchgate.net/publication/278078354_Eligen_Technology_for_Oral_Delivery_of_Proteins_and_Peptides
Eligen Technology for Oral Delivery of Proteins and Peptides. ... of novel proprietary delivery agents that have enabled the oral delivery of a large number of therapeutic proteins and peptides ...
https://www.sciencedirect.com/science/article/pii/S0168365999001467
This challenge has been successfully met in the formulation of several peptide and protein drugs using the DepoFoam™, multivesicular lipid-based drug delivery system. DepoFoam technology consists of novel multivesicular liposomes characterized by their unique structure of multiple non-concentric aqueous chambers surrounded by a network of lipid membranes.Author: Qiang Ye, John Asherman, Mark Stevenson, Elizabeth Brownson, Nandini V Katre
https://www.researchgate.net/publication/11847769_Oral_Delivery_of_Biologically_Active_Parathyroid_Hormone
Oral Delivery of Biologically Active Parathyroid Hormone. ... The orally-absorbed PTH is biologically active as demonstrated in a rat model of osteoporosis. ... Protein and Peptide Drug Delivery ...
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