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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100725/
May 21, 2014 · Novel gemini cationic lipids with carbamate groups for gene delivery. ... a series of Gemini cationic lipids with carbamate linkers between headgroups and hydrophobic tails were synthesized. They have the hydrocarbon chains of 12, 14, 16 and 18 carbon atoms as tails, designated as G12, G14, G16 and G18, respectively. ... these novel Gemini ...Author: Yi Nan Zhao, Yi Nan Zhao, Farooq Qureshi, Shu Biao Zhang, Shao Hui Cui, Bing Wang, Hui Ying Chen, Ho...
https://www.ncbi.nlm.nih.gov/pubmed/25045521
May 21, 2014 · Novel gemini cationic lipids with carbamate groups for gene delivery. ... These Gemini cationic lipids were prepared into cationic liposomes for the study of the physicochemical properties and gene delivery. The DNA-bonding ability of these Gemini cationic liposomes was much better than their mono-head counterparts (designated as M12, M14, M16 ...Author: Yi Nan Zhao, Yi Nan Zhao, Farooq Qureshi, Shu Biao Zhang, Shao Hui Cui, Bing Wang, Hui Ying Chen, Ho...
https://www.researchgate.net/publication/264092956_Novel_Gemini_cationic_lipids_with_carbamate_groups_for_gene_delivery
Custom-made cationic lipids (Oh & Park, 2009) and cationic gemini lipids ( Zhao et al., 2014) have also been explored as gene delivery vehicles. Despite their promise in in vitro trials, most of ...
https://pubs.rsc.org/en/content/articlelanding/2014/tb/c3tb21506g
Gene transfection efficiency was maximal at a chain length of 14, as G14 can silence about 80% of luciferase in A549 cells. Cell uptake results indicate that Gemini lipid delivery systems could be internalised by cells very efficiently. Thus, the Gemini cationic lipids could be used as synthetic non-viral gene delivery carriers for further studies.Author: Yi Nan Zhao, Yi Nan Zhao, Farooq Qureshi, Shu Biao Zhang, Shao Hui Cui, Bing Wang, Hui Ying Chen, Ho...
https://www.sciencedirect.com/science/article/pii/S0968089618307181
Jul 23, 2018 · In summary, the novel carbamate-linked quaternary ammonium cationic lipids with unsaturated hydrophobic chains were prepared for gene delivery. Compared with the saturated counterparts, unsaturated quaternary ammonium cationic liposomes have shown a superior pDNA binding ability and more efficient in vitro transfection.Author: Hengjun Zhou, Hengjun Zhou, Jian Yang, Yanyan Du, Shuang Fu, Chenxi Song, Defu Zhi, Yinan Zhao, Huiy...
https://www.researchgate.net/publication/325258290_Novel_carbamate-linked_quaternary_ammonium_lipids_containing_unsaturated_hydrophobic_chains_for_gene_delivery
Novel Gemini cationic lipids with carbamate groups for gene delivery ... function relationship of how these factors affect cationic lipids on gene delivery performance. ... of terminal groups on ...
https://pubs.acs.org/doi/10.1021/jm901022t
Gene therapy based on gene delivery is a promising strategy for the treatment of human disease. Here we present data on structure/biological activity of new biodegradable cholesterol-based cationic lipids with various heterocyclic cationic head groups and linker types. Enhanced accumulation of nucleic acids in the cells mediated by the lipids was demonstrated by fluorescent microscopy and flow ...Author: Darya A. Medvedeva, Mikhail A. Maslov, Roman N. Serikov, Nina G. Morozova, Galina A. Serebrenikova, ...
https://www.sciencedirect.com/science/article/pii/S0001868617303871
As a sister paper, this review aims to highlight the advances in cationic lipids with different linkers for gene delivery, and provides some suggestions on the development of cationic lipids via the discussion. 2. Ether linker and ester linker. Cationic lipids containing ester or …Author: Defu Zhi, Yuchao Bai, Jian Yang, Shaohui Cui, Yinan Zhao, Huiying Chen, Shubiao Zhang
https://pubs.acs.org/doi/abs/10.1021/bc300381s
Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are especially attractive because they can be easily synthesized and extensively characterized. Additionally, they can best facilitate the elucidation of structure–activity relationships by modifying each of …Author: Defu Zhi, Shubiao Zhang, Shaohui Cui, Yinan Zhao, Yinhuan Wang, Defeng Zhao
http://europepmc.org/articles/PMC4394498
Mar 11, 2015 · Novel cholesterol-based cationic lipids as transfecting agents of DNA for efficient gene delivery. Jia Ju Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.Author: Jia Ju, Meng-Lei Huan, Ning Wan, Hai Qiu, Si-Yuan Zhou, Bang-Le Zhang
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