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http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
http://mysticpharmaceuticals.com/nose-to-brain-delivery/
Mystic offers patient-centric delivery systems for systemic intranasal, nose-to-brain, ophthalmic, sublingual, dermal and oral delivery. Our delivery platforms and integration services provides a custom optimized delivery system in combination with your drug or biologic to meet your technical product and market requirements.
https://www.ncbi.nlm.nih.gov/pubmed/31126978
The nose-to-brain route has also been demonstrated in human studies with solution and particle formulations. The entry of device manufacturers into the arena will enable the benefits of this delivery route to become translated into approved products.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pubmed/31837821
Dec 06, 2019 · Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while minimizing systemic exposure. The objective of this work was to engineer a nanocarrier intended to enhance N-to-B delivery of RNA and to explore its potential utility for …Author: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel ...
Brainose Mission: To provide the huge population that benefits from cannabis-derived therapeutics accessibility to these important medications in a safe, efficient, simple and friendly manner. Our Vision is to enable safe, effective and fast delivery of cannabis-derived therapeutics from the nose to the brain with minimal undesired local and
https://www.sciencedirect.com/science/article/pii/S2211383516300211
Brain delivery of macromolecular therapeutics (e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier (BBB).Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs, new challenges arise for intranasal delivery of proteins because of their ...Author: Tingting Lin, Tingting Lin, Ergang Liu, Ergang Liu, Huining He, Meong Cheol Shin, Meong Cheol Shin, ...
https://www.youtube.com/watch?v=q6uCIgWQkwM
Feb 06, 2017 · Direct transport of drug through nose to brain by passing BBB.Author: Sagar Savale
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00088
The ability to deliver therapeutically relevant amounts of drugs directly from the nasal cavity to the central nervous system to treat neurological diseases is dependent on the availability of efficient drug delivery systems. Increased delivery and/or therapeutic effect has been shown for drugs encapsulated in nanoparticles; however, the factors governing the transport of the drugs and/or the ...Author: Alpesh Mistry, Snjezana Stolnik, Lisbeth Illum
https://www.mdpi.com/1999-4923/11/2/84/pdf
Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14–17]. These drug administration pathways are characterized by many advantages such as increasedAuthor: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
http://jpet.aspetjournals.org/content/jpet/early/2019/05/24/jpet.119.258152.full.pdf
Nose to brain mechanism of delivery For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area; with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
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