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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The non-viral vectors are Naked DNA, particle based and chemical based. They are administered by direct administration (plasmid DNA/Naked DNA)/ chemical /physical. Most of cardiovascular clinical trials use non-viral vectors as a mode of gene transfer.Author: Murali Ramamoorth, Aparna Narvekar
https://www.sciencedirect.com/topics/medicine-and-dentistry/non-viral-vector
Non-viral vectors. Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed. Furthermore, physical approaches including, for example, electroporation and gene ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835126/
Apr 30, 2009 · The potential of these nonviral biological entities to act as clinical gene therapy delivery vehicles has already been shown in clinical trials using bacteria-mediated gene transfer and with sufficient development, these entities will complement the established delivery techniques for gene therapy applications.Author: Yiqi Seow, Matthew J Wood
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Since the initial studies, hundreds of cationic lipids have been synthesized as candidates for non-viral gene delivery and a few made it to clinical trials [85,86]. Cationic lipids can be used to form lipoplexes by directly mixing the positively charged lipids at the physiological pH with the negatively charged DNA.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.sciencedirect.com/science/article/pii/S0024320520302988
Non-viral vectors such as cationic lipids and polycationic polymers are used as DNA delivery agents in gene therapy [ 8, 34 ]. These molecules form electrostatic interactions with DNA, thereby protects DNA from nucleases and cellular defense mechanism.Author: Balamurugan Shanmugaraj, Lohanathan Bharathi Priya, B. Mahalakshmi, Shanmugam Subbiah, Rouh-Mei Hu, ...
https://onlinelibrary.wiley.com/doi/full/10.1002/jgm.3092
Apr 16, 2019 · Non‐viral gene delivery systems show a lower transfection efficacy and transient gene expression compared to viral vectors; however, non‐viral vectors are of much lower immunogenicity than the viral vectors.Author: Weiqi Wang, Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu
https://link.springer.com/article/10.1007%2Fs00253-003-1321-8
Apr 29, 2003 · A delivery vehicle (vector), of either viral or non-viral origin, must be used to carry the foreign gene into a cell. Viral vectors take advantage of the facile integration of the gene of interest into the host and high probability of its long-term expression but are plagued by safety concerns.Author: M. Thomas, A. M. Klibanov
https://www.scitechnol.com/peer-review/nonviral-vectors-for-cystic-fibrosis-therapy-recent-advances-X9at.php?article_id=8399
Jun 28, 2018 · Non-Viral Vectors for Cystic Fibrosis Therapy: Recent Advances Faisal Qaisar, Anum Habib, Noor Muhammad and Zia ur Rehman * Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, PakistanAuthor: Faisal Qaisar, Anum Habib, Noor Muhammad, Zia ur Rehman
Learn how BMoGen is utilizing their unique expertise to provide gene editing services including fee-for-service and non-viral transposon based gene delivery platforms that address complex gene delivery and gene editing enabling scientists and bio-therapeutics companies to create life …
https://www.researchgate.net/publication/324531125_Chitosan_in_Non-Viral_Gene_Delivery_Role_of_Structure_Characterization_Methods_and_Insights_in_Cancer_and_Rare_Diseases_Therapies
Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less safety risks...
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