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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · This Review introduces the biological barriers to gene deliveryin vivoand discusses recent advances in material sciences, nanotechnology and nucleic acid chemistry …Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Viral vectors are still considered the primary choice for gene delivery, evident by their use in 67% of current clinical trials versus less than 1% of non-viral vectors . For novel nanomaterials, techniques and gene delivery approaches continue to be developed, the key challenge will be to balance transfection efficiency, targeting specificity ...Author: Michael K. Riley, Wilfred Vermerris
https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Highly Branched Poly(β-amino esters) for Non-Viral Gene Delivery: High Transfection Efficiency and Low Toxicity Achieved by Increasing Molecular Weight. Biomacromolecules 2016 , 17 (11) , 3640-3647.Author: Meredith A. Mintzer, Eric E. Simanek
https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3092
A brief overview is provided of the recent advances in the non‐viral gene delivery methods that are being used to activate cancer‐specific immune responses. Furthermore, the tumor microenvironment‐responsive synergistic strategies that modulate the immune response by targeting various signaling pathways are discussed.Author: Weiqi Wang, Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu
https://onlinelibrary.wiley.com/doi/full/10.1002/jgm.3092
Apr 16, 2019 · Non‐viral gene delivery systems show a lower transfection efficacy and transient gene expression compared to viral vectors; however, non‐viral vectors are of much lower immunogenicity than the viral vectors.Author: Weiqi Wang, Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu
https://www.sciencedirect.com/science/article/pii/S0142961218302862
Nevertheless, with the rapid development of various synthetic vectors, non-viral vectors are very likely to provide unique advantages over viral vectors in these fields. Here, we review recent advances of non-viral vectors for CRISPR/Cas9 delivery in vivo and focus on those non-viral delivery systems applied for CRISPR/Cas9-based gene therapy.Author: Ling Li, Ling Li, Shuo Hu, Xiaoyuan Chen
https://www.ijpsnonline.com/Issues/4681.pdf
Aggarwal et al: Polyplex: A Promising Gene Delivery System 4681 Review Article Polyplex: A Promising Gene Delivery System Rohan Aggarwal*, Monika Targhotra, Bhumika Kumar, P.K Sahoo and Meenakshi ... Events in gene transfection process of non-viral vector is similar to the viral vector. The events are represented in Figure 2.
https://www.nature.com/articles/natrevmats201756
Sep 12, 2017 · In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile therapeutic with the potential to prevent and treat a staggering range …Author: Khalid A. Hajj, Kathryn A. Whitehead
https://www.europepmc.org/articles/PMC4347098/
Europe PMC is an archive of life sciences journal literature. Find the latest peer-reviewed research articles and preprints on Coronavirus here.Author: Murali Ramamoorth, Aparna Narvekar
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