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https://www.sciencedirect.com/science/article/pii/S135964461830254X
Non-invasive insulin formulations currently in clinical trials have been reviewed. • So far only two such products have secured FDA approval; Exubera ® and Afrezza ®.. Most of the non-invasive insulin delivery research focuses on the oral route.Author: Najma Easa, Raid G. Alany, Mark Carew, Anil Vangala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia. Therefore, the need exists for delivering insulin in a minimally invasive or noninvasive and in most physiological way.
http://sphinxsai.com/sphinxsaiVol_2No.1/PharmTech_Vol_2No.1/PharmTech_Vol_2No.1PDF/PT=96%20(603-614).pdf
studied for non-parenteral delivery1, 2. Consequently, the results of research into several aspects of the delivery of the insulin are available. In recent years, there has been a great deal of interest in the exploitation of non-invasive routes for insulin delivery, and their development by …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944732/
Sep 11, 2019 · Similarly, the lungs are exceptionally permeable to macromolecules; thus, pulmonary delivery can be an effective non-invasive route for protein delivery . It has been reported that inhaled insulin was more rapidly absorbed than subcutaneously injected insulin and provides an enhanced physiological response to a meal . Likewise, the transdermal ...Author: Rajiv Bajracharya, Jae Geun Song, Seung Yun Back, Hyo-Kyung Han
https://www.nature.com/articles/nrd.2018.183
Nov 30, 2018 · The requirement for delivery by injection is currently a limitation for the use of biologic drugs such as antibodies. In this Review, Mitragotri and colleagues discuss advances made in non ...Author: Aaron C. Anselmo, Yatin Gokarn, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S0169409X07001913
It seems that a transdermal delivery system for insulin is an attractive option. Although progress in the transdermal delivery of insulin and other peptides seems encouraging, it is still doubtful whether this delivery route provides a general approach to the non-invasive delivery of insulin.Author: El-Sayed Khafagy, Mariko Morishita, Yoshinori Onuki, Kozo Takayama
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