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https://www.tandfonline.com/doi/abs/10.1080/026520499288672
Non-ionic surfactant vesicles (niosomes) have shown promise as cheap, chemically stable alternatives to liposomes. Niosomes of spans (Sorbitan monoesters) have shown promise of commercial exploitation. Hence, niosomes were prepared of 5-fluorouracil (FU) using different spans.Author: A. Namdeo, N. K. Jain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666243/
May 09, 2015 · Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study, the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, on the skin permeation and antimelanoma efficacy of 5-fluorouracil …Author: Tawona N. Chinembiri, Minja Gerber, Lissinda Du Plessis, Jan L. Du Preez, Jeanetta Du Plessis
https://www.ncbi.nlm.nih.gov/pubmed/21799471
Topical 5-fluorouracil (5-FU) is used for the treatment of actinic keratosis and nonmelanoma skin cancer. Unfortunately, 5-FU per se shows a poor percutaneous permeation, thus reducing its anticancer effectiveness after topical administration.Author: Iqrar Ali Alvi, Jitender Madan, Dinesh Kaushik, Satish Sardana, Ravi Shankar Pandey, Asgar Ali
https://www.sciencedirect.com/science/article/pii/S2311300616301847
For the last 70 years, the fluoropyrimidine 5-fluorouracil (5-FU) has been positioned as a first line chemotherapy in the treatment of various cancers including colorectal, head, neck and breast cancers.10, 11 This combination has multiple mechanisms of cytotoxicity including the inhibition of thymidylate synthase,...Author: Suriyakala Perumal Chandran, Suriyakala Perumal Chandran, Satheesh Babu Natarajan, Sowmiya Chandrase...
https://www.researchgate.net/publication/5659081_Innovative_bola-surfactant_niosomes_as_topical_delivery_systems_of_5-fluorouracil_for_the_treatment_of_skin_cancer
Nov 11, 2019 · Niosomal delivery system for 5-fluorouracil (5-FU) consisting of a,x-hexadecyl-bis-(1-aza-18-crown-6), cholesterol, and Span 80 ® was investigated …
http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=2001&volume=53&issue=8&spage=1069
The applied dose was also optimized. Using the improved design and the optimum dose, an ultradeformable formulation was compared with four traditional liposomes for skin delivery of 5‐fluorouracil (5‐FU). The best receptor was 50% aqueous ethanol and the optimum dose was 20 μL.Author: Gamal M. M. El Maghraby, Adrian C. Williams, Brian W. Barry
https://www.sciencedirect.com/science/article/pii/S0378517307009404
An innovative niosomal system made up of α,ω-hexadecyl-bis-(1-aza-18-crown-6) (Bola), Span 80 ® and cholesterol (2:5:2 molar ratio) was proposed as a topical delivery system for 5-fluorouracil (5-FU), largely used in the treatment of different forms of skin cancers.Author: Donatella Paolino, Donato Cosco, Rita Muzzalupo, Elena Trapasso, Nevio Picci, Massimo Fresta
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