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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711206/
The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities allowing for effective delivery of drugs and biomacromolecules to the central nervous system (CNS) is of great need and importance for treatment of neurodegenerative disorders.Author: A.V. Kabanov, E.V. Batrakova
https://www.ncbi.nlm.nih.gov/pubmed/15134486
New technologies for drug delivery across the blood brain barrier. Kabanov AV(1), Batrakova EV. Author information: (1)Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha NE 68198-6025, USA. [email protected]: A.V. Kabanov, E.V. Batrakova
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1381-6128&volume=10&issue=12&spage=1355
Abstract: The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities allowing for effective delivery of drugs and biomacromolecules to the central nervous system (CNS) is of great need and importance for treatment of neurodegenerative disorders.Author: A.V. Kabanov, E.V. Batrakova
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.brainfacts.org/Brain-Anatomy-and-Function/Anatomy/2014/Blood-Brain-Barrier
Jul 02, 2014 · Boado RJ, Hui EK, Lu JZ, Pardridge WM. Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. Journal of Pharmacology and Experimental Therapeutics. 333(3): 961-969 (2010). Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease.
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery William A. Banks 1 Nature Reviews Drug Discovery volume 15 , pages 275 – 292 ( 2016 ) Cite this articleAuthor: William A. Banks
https://www.prnewswire.com/news-releases/drug-delivery-across-blood-brain-barrier-market-worth-4-6-billion-by-2026--300975787.html
Reports say that the global drug delivery across brain barrier market size is expected to reach USD 4.6 billion by 2026, according to a new report by Grand View Research, Inc. registering a CAGR ...
https://stories.abbvie.com/stories/how-to-overcome-blood-brain-barrier-to-deliver-new-medicines.htm
Jul 18, 2016 · The blood-brain barrier (BBB) is a complex and intricate system of cells that come together around the blood vessels in the brain. It maintains proper function of the brain, but it also makes it harder to discover and develop new medicines to treat diseases of the brain, such as Alzheimer’s disease, Parkinson’s and others.
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