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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
https://www.optinose.com/exhalation-delivery-systems/nasal-delivery-challenges
Nasal Delivery Challenges Despite easy access, the complex and dynamic geometry of the nose makes reliable and efficient delivery of drugs to mucosal surfaces high and deep in the nose challenging. The nasal valve is the narrowest segment of the respiratory tract, accounting for up to 80% of nasal resistance and almost half of total respiratory resistance.
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/nasal/
Your patients deserve better nasal drug delivery than aqueous nasal sprays for allergic rhinitis. These sprays can drip down the throat and out of the nose, causing irritation, embarrassment, and unpleasant aftertastes. 3M can help deliver your treatments with intuitive patient-friendly nasal MDIs.
https://www.contractpharma.com/issues/2019-01-01/view_features/nasal-drug-delivery
One of the benefits of nasal delivery for systemic drugs is that they can bypass the blood-brain barrier and enter the brain directly via the olfactory and trigeminal nerve pathways. 2-4 Additionally, the nasal cavity has a thin, well vascularised mucosa. 5 Drug molecules can transfer across this layer directly to the systemic blood circulation 6,7 thereby avoiding first-pass hepatic and/or intestinal metabolism.
http://intranasal.net/DeliveryTechniques/default.htm
Unfortunately, nasal dropper delivery of medications requires a fairly cooperative patient or actual physical restraint of the patient to position them in a semi-recumbent or other unusual position (usually requiring at least two adults to hold in position) so the medicine will run back into the nose and not out onto their lip or throat.
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