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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
https://www.optinose.com/exhalation-delivery-systems/nasal-delivery-challenges
Nasal Delivery Challenges Despite easy access, the complex and dynamic geometry of the nose makes reliable and efficient delivery of drugs to mucosal surfaces high and deep in the nose challenging.
https://www.contractpharma.com/issues/2019-01-01/view_features/nasal-drug-delivery
One of the benefits of nasal delivery for systemic drugs is that they can bypass the blood-brain barrier and enter the brain directly via the olfactory and trigeminal nerve pathways. 2-4 Additionally, the nasal cavity has a thin, well vascularised mucosa. 5 Drug molecules can transfer across this layer directly to the systemic blood circulation 6,7 thereby avoiding first-pass hepatic and/or intestinal metabolism.
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
Direct-Haler A/S has invented and developed a novel nasal delivery device and nasal delivery principle. The innovation takes advantage of the patient’s anatomy to improve nasal delivery effectiveness and convenience. The integrated nasal device and delivery method enables nasal delivery of very fine particles, without the risk of pulmonary ...
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The nasal route of drug delivery is one such alternate route that provides access to highly vascularized mucosa, which can be exploited as an interesting site for local drug delivery, systemic drug delivery, and targeted drug delivery (CNS).
http://intranasal.net/DeliveryTechniques/default.htm
A second method of intranasal drug delivery is to take a solubilized medication (liquid form) and drip it into the nose a few drops at a time, allowing it to run down onto the nasal mucosa. This can be done using a syringe or in some instances using the packaged form …
Nasadol is an exciting new and unique way to take CBD! Nasadol's nasal delivery of CBD means faster and more efficient relief for you.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/Overview/default.htm
Intranasal (IN) medication delivery is simply another option or method to deliver therapeutic medications to the patient’s blood stream to achieve a desired clinical effect. It is a tool in the therapeutic armamentarium just as oral, rectal, sublingual, intramuscular and intravenous delivery methods are also tools to deliver medications.
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