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https://www.ncbi.nlm.nih.gov/pubmed/22834197
Delivery of drug therapeutics across the blood-brain barrier is a challenging task for pharmaceutical scientists. Nasal-to-CNS drug delivery has shown promising results in preclinical efficacy models and investigatory human clinical trials.Author: Margaret S Landis, Tracey Boyden, Simon Pegg
https://www.future-science.com/doi/10.4155/tde.11.149
Nasal-to-CNS drug delivery has shown promising results in preclinical efficacy mode... Delivery of drug therapeutics across the blood–brain barrier is a challenging task for pharmaceutical scientists.Author: Margaret S Landis, Tracey Boyden, Simon Pegg
http://www.thepharmajournal.com/vol2Issue1/Issue_march_2013/14.pdf
drug delivery is the blood-brain barrier (BBB), which limits the access of most drugs to the brain. Advances in understandings of the cell biology of the BBB have made new avenues and possibilities for improved drug delivery to the CNS. It is well established that the BBB is a membranous barrier that segregates the brain
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
Drug delivery devices have been found to play an important role in ensuring that the entire drug is delivered to the target site in the nasal cavity. It is difficult to precisely deliver the drug to the olfactory region of the human nasal cavity as this region is found high …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17]. These drug administration pathways are characterized by many advantages such as increased patient compliance, high safety, remarkable ease of administration and rapid ...Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Drug delivery across the physiological barriers of the brain is the bottleneck for the treatment of CNS disorders and brain tumors. The delivery of most drugs to the CNS is limited by the anatomical structure at the BBB and BCSFB.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.sciencedirect.com/science/article/pii/S0169409X11002791
Intranasal delivery of large molecular weight biologics such as proteins, gene vectors, and stem cells is a potentially useful strategy to treat a variety of diseases/disorders of the CNS including stroke, Parkinson's disease, multiple sclerosis, Alzheimer's disease, epilepsy, and psychiatric disorders.Author: Jeffrey J. Lochhead, Robert G. Thorne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · Drug delivery technologies such as liquid, semi-solid or particulate formulations are important to deliver pharmaceutical compounds safely to their desired site of therapeutic activity . A highly critical point in drug delivery is the low availability of drugs in the central nervous system (CNS) due to the blood-brain barrier.Author: Stella Gänger, Katharina Schindowski
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567259/
Historically, intranasal drug delivery has been utilized for local treatments such as allergies, etc. Recently, the use of intranasal route as a means of delivering therapeutics to the CNS has gained tremendous interest and momentum .Author: Mihir B. Chauhan, Neelima B. Chauhan
https://drug-dev.com/cns-delivery-bypassing-the-bbb-drug-delivery-from-the-olfactory-mucosa-to-the-cns/
T.R. Shantha, MD, PhD, FACA, explores and explains how therapeutic and non- therapeutic agents can reach the brain, bypassing through the formidable BBB based on the unique microanatomic and physiologic characteristics of the nasal olfactory mucosal route and its CNS connections that allow transportation directly into the CNS.
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