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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
Nasal Mucoadhesive Drug Delivery Systems. The area of the normal human nasal mucosa is approximately 150 cm 2, a highly dense vascular network and relatively permeable membrane structure; all these factors make nasal cavity interesting. Drawbacks are local toxicity/irritation mucociliary clearance of 5 min, presence of proteolytic enzymes, and influence of pathological conditions (cold and allergies).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
In recent years, many such mucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effects. Dosage forms designed for mucoadhesive drug delivery should be small and flexible enough to be acceptable for patients and should not cause irritation.
https://www.researchgate.net/profile/Zaheer_Abbas33/publication/286292372_Mucoadhesive_in_situ_gels_as_nasal_drug_delivery_systems_An_overview/links/5a962d49a6fdccecff0929c8/Mucoadhesive-in-situ-gels-as-nasal-drug-delivery-systems-An-overview.pdf
Mucoadhesive in situ gels as nasal drug delivery systems: an overview N G N Swamy a, * , Zaheer Abbas b a Department of Pharmaceutics, Government College of Pharmacy, Subbaiah Circle, Bangalore ...
https://www.sciencedirect.com/science/article/pii/S0378517320301502
Intranasal delivery requires the localization of drug in the nasal cavity for sufficient time for absorption, without dripping outside the nose or running to the throat. Therefore, nanoparticles must be incorporated into mucoadhesive formulations that maintain the advantages of nanosizing simultaneously with localization inside the nasal cavity.Author: Areen Alshweiat, Areen Alshweiat, IIdikó Csóka, Ferenc Tömösi, Tamás Janáky, Anita Kovács, Róbert Gá...
https://www.pharmatutor.org/articles/nasal-drug-delivery-system-complete-review
The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in ...
https://www.researchgate.net/publication/319563818_A_SYSTEMATIC_REVIEW_ON_MUCOADHESIVE_DRUG_DELIVERY_SYSTEM
Sep 01, 2017 · Nasal drug delivery system. The nasal mucosa has a surface area of about 150-200 cm 2 but the residence time in the nasal . ... Factors Affecting Mucoadhesive Drug Delivery Systems . …Author: Hemal Tandel
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