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https://www.researchgate.net/publication/49840496_Nasal_Drug_Delivery_in_Humans
Nasal Drug Delivery in Humans Christoph Bitter a ⭈ Katja Suter- Zimmermann a ⭈ Christian Surber a,b a Hospital Pharmacy and b Department of Dermatology, University of Basel Hospital, Basel ...
https://reference.medscape.com/medline/abstract/21325837
The nasal mucosa is--compared to other mucosae--easily accessible. Intranasal drug administration is noninvasive, essentially painless and particularly suited for children. Application can be performed easily by patients or by physicians in emergency settings. Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic).
https://www.ncbi.nlm.nih.gov/pubmed/21325837
Nasal drug delivery in humans. Bitter C, Suter-Zimmermann K, Surber C. Intranasal administration is an attractive option for local and systemic delivery of many therapeutic agents. The nasal mucosa is--compared to other mucosae--easily accessible.Author: Christoph Bitter, Katja Suter-Zimmermann, Christian Surber
https://www.semanticscholar.org/paper/Nasal-drug-delivery-in-humans.-Bitter-Suter-Zimmermann/c8fda487bdbd826faf8a36319814e4cdfb09018b
The nasal mucosa is--compared to other mucosae--easily accessible. Intranasal drug administration is noninvasive, essentially painless and particularly suited for children. Application can be performed easily by patients or by physicians in emergency settings. Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic).
https://www.researchgate.net/profile/Christian_Surber/publication/49840496_Nasal_Drug_Delivery_in_Humans/links/557f8c0c08aeea18b779668a/Nasal-Drug-Delivery-in-Humans.pdf?origin=publication_detail
Nasal Drug Delivery in Humans 23 first line of defense for the body’s airway as it copes with more than 500 liters of air that are fil-tered hourly into the lung.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · In the context of nasal drug delivery, perivascular spaces along the olfactory and trigeminal nerves acting as lymphatic pathways between the CNS and the nose have been implicated in the transport of molecules from the nasal cavity to the CNS .Author: Per Gisle Djupesland
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
It is therefore required to explore either alternate routes or specialized delivery technologies that can result in improved and effective drug delivery options. The nasal route of drug delivery is one such alternate route that provides access to highly vascularized mucosa, which can be exploited as an interesting site for local drug delivery ...
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Direct delivery of therapeutics from the nasal cavity into the CNS (IN delivery) bypasses the BBB and provides an alternative to invasive methods of drug administration [1, 2]. Noninvasive IN delivery targets therapeutics to the CNS, reducing systemic exposure and side effects; this can be advantageous for delivery of many CNS therapeutics ...Author: Leah R Hanson, William H Frey, William H Frey
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