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https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
nasal formulations of, for example, hormones, vaccines and compounds for the treatment of migraine, have also reached the market – and more still are progressing through clinical development. As Michael Sheckler of Javelin Pharmaceuticals (formerly IDDS) reports herein, Greystone Associates predicts that the nasal drug delivery market will enjoy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835450/
Oct 17, 2019 · Yang and coworkers investigated the potential of liposomal nasal delivery of rivastigmine, an AD drug that is currently available as an oral dosage form . Liposomal formulations were compared with solutions containing poloxamer 188 as a permeation enhancer.Author: Soon-Seok Hong, Kyung Taek Oh, Han-Gon Choi, Soo-Jeong Lim
https://www.pharma.dupont.com/pharmaceutical-applications/pharmaceutical-excipients/nasal-delivery.html
Nasal drug delivery has been in use for many years, primarily for the delivery of small molecules for use in respiratory and allergic rhinitis. Nasal drug delivery offers an alternative route of administration over injection. METHOCEL™ Cellulose Ethers have unique capabilities to control solution viscosity,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · Effective drug formulations developed for intranasal administration should therefore penetrate the nasal mucus and adhere to the local epithelium to minimize mucocilliary clearance. Permeability of mucus depends on the properties of the invading substance, mucus thickness as well as mucus consistency.Author: Stella Gänger, Katharina Schindowski
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795377/
Aug 14, 2013 · In intranasal delivery, it improves the nasal residence time of the formulation by decreasing the mucociliary clearance due to its bioadhesive properties [ 77, 78 ]. This excipient could be used to elaborate different types of intranasal formulations including solution, dispersion, and powder formulation.Author: Matthias van Woensel, Nathalie Wauthoz, Rémi Rosière, Karim Amighi, Véronique Mathieu, Florence Lefr...
https://www.intechopen.com/books/drug-discovery-and-development-from-molecules-to-medicine/intranasal-drug-administration-an-attractive-delivery-route-for-some-drugs
The most common use is for treatment of local symptoms e.g. nasal congestion in the course of a common rhinitis or inflammation linked to allergic rhinitis. The medications intended for local activity are well established and can be found across the globe in every pharmacy and drug store.Author: Degenhard Marx, Gerallt Williams, Matthias Birkhoff
https://www.researchgate.net/publication/49840496_Nasal_Drug_Delivery_in_Humans
Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic). Nasal application circumvents gastrointestinal degradation and hepatic first-pass metabolism of the drug. The drug, the vehicle and the application device form an undividable triad.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Metered-dose spray pumps. Metered spray pumps have, since they were introduced some four decades ago, dominated the nasal drug delivery market (Table 1). The pumps typically deliver 100 μl (25–200 μl) per spray, and they offer high reproducibility of the emitted dose and plume geometry in …Author: Per Gisle Djupesland
https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
Pump Delivery. Pump delivery testing should be performed to assess delivery and reproducibility. Typically, the weight of individual sprays should be within 15% or the target weight, and their mean within 10% of the target weight .
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