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https://www.nature.com/articles/s41541-020-0172-y
Mar 24, 2020 · Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice Skip to main content Thank you for visiting nature.com.Author: Hiroki Takeuchi
https://www.omicsonline.org/open-access/nose-to-brain-drug-delivery-a-recent-update.pdf
Nose to Brain Drug Delivery: A Recent Update
http://www.thepharmajournal.com/vol2Issue1/Issue_march_2013/14.pdf
olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.
https://www.snbl-nds.com/application/
Advantages of Nasal Application for Nose-to-Brain Delivery Enhanced delivery of drugs to the brain that may show difficulty in penetrating the blood-brain-barrier (BBB) Reduced number of adverse effects resulting from systemic exposure of the drug A more patient-friendly option when compared with invasive delivery routes such as intrathecal ...
https://www.snbl-nds.com/technology/
SNBL has developed a proprietary nasal drug delivery technology, μco™ System, consisting of a powder carrier technology (μco™ Carrier) designed for increased drug absorption through its muco-adhesive properties and a delivery device technology designed for simple use, and complete and consistent delivery of intranasal powder formulations.
https://www.researchgate.net/publication/339098080_Nose-to-Brain_Delivery
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties ...
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
LAS VEGAS—The nasal mucosa in the upper third of the nasal cavity provides a direct pathway from the external environment to the brain and, according to William H. Frey II, PhD, that pathway can be used to noninvasively deliver therapeutics into the brain.This pathway effectively bypasses the blood–brain barrier and avoids the systemic exposure and side effects associated with therapeutics ...
http://pubs.sciepub.com/ajps/3/5/2/
1. Introduction. Nasal drug delivery, which is in the focus of this review article, has received a significant attention in recent years as a convenient and reliable route, not only for local but also for the systemic administration of drugs [1, 2, 3].The nasal cavity offers a number of distinctive advantages for systemic delivery such as [4, 5, 6]: . I- A large surface area for drug absorption.
https://www.sciencedirect.com/science/article/pii/S0171933509000211
Intranasal delivery of cells to the brain. ... This biological pathway of cell migration from the nasal mucosa to the brain thus provides an opportunity for the development of cell delivery methods for therapeutic and experimental use in treating neurodegenerative disorders and creating brain …
http://jpet.aspetjournals.org/content/jpet/early/2019/05/24/jpet.119.258152.full.pdf
delivery to the brain via established quantification techniques. We have also highlighted clinical studies, where nose to brain delivery was the intended outcome. Nose to brain mechanism of delivery For the purposes of drug delivery, the nasal cavity is divided into the respiratory area
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic ...
https://www.nature.com/articles/s41598-019-46032-y
Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease ... reported for the first time for the brain delivery of DH which might result in the development of an ...
https://www.youtube.com/watch?v=q6uCIgWQkwM
Feb 05, 2017 · Direct transport of drug through nose to brain by passing BBB.
https://www.researchgate.net/publication/49840496_Nasal_Drug_Delivery_in_Humans
Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver drugs to the brain bypassing the blood-brain barrier (BBB).
http://intranasal.net/Peer%20Reviewed%20literature/Talegaonkar,%20Intranasal%20delivery%20-%20An%20approach%20to%20bypass%20the%20blood%20brain%20barrier,%20I%20J%20Pharm%202004.pdf
Intranasal delivery: An approach to bypass the blood brain barrier S. Talegaonkar, P. R. Mishra ABSTRACT The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins
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