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https://www.copybook.com/companies/management-forum/articles/controlled-particle-dispersion-effective-nasal-delivery-from-a-versatile-flexible-technology-platform
Management Forum. Today's nasal delivery technology - the spray pump - has been the status quo for over 25 years. Despite the fact that up to 90% of the drug ends up in the stomach, somehow spray pumps became accepted as nasal drug delivery devices. Increasing demands fortargeted deposition, less peripheral delivery, fewerside effects ...
https://management-forum.co.uk/product/details/936/nasal-drug-delivery
Per G Djupesland, M.D., Ph.D. is the inventor of OptiNose’s patented, Breath Powered™ Bi-Directional™ nasal drug delivery technology. He has been Chief Scientific Officer of OptiNose since 2000 and is in charge of scientific efforts at OptiNose.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
https://www.pharmatutor.org/articles/nasal-drug-delivery-system-complete-review
About Authors: Dharmendra Kumar*1, Sumedha Bansal1 1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pardesh, India, 250005 *[email protected] Abstract: In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/DeliveryTechniques/default.htm
Squeeze bottle delivery is another option for nasal drug delivery. However this technique is not able to deliver a measure dose of drug. Mucosal coverage is also dependent on the patient applying adequate pressure to the device to deliver the drug - so delivery is very variable.
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