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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including ...Author: Michael K. Riley, Wilfred Vermerris
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990059/
In this review we aim to highlight the molecular role of TRAIL in apoptosis and interaction with cancer stem cells (CSCs) self-renewal pathways. Finally, we also aim to discuss the different roles of gene delivery systems, mesenchymal cells, and nanotechnology designs in TRAIL gene delivery.Author: George E Naoum, Fady Tawadros, Ammad Ahmad Farooqi, Muhammad Zahid Qureshi, Sobia Tabassum, Donald J...
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have …Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://directorsblog.nih.gov/tag/nanotechnology/
Sep 17, 2019 · Their gene-editing contents are then released into the cytoplasm where they can begin making their way to a cell’s nucleus within a few hours. Further study in lab dishes showed that nanocapsule delivery of CRISPR led to precise gene editing of up to about 80 percent of human cells with little sign of toxicity.
http://www.phys.sinica.edu.tw/TIGP-NANO/Course/2012_Spring/classnotes/NanoB_20120511.pdf
Nanotechnology in Gene and Drug Delivery. Gene Therapy • Gene therapy is a technique for correcting defective genes responsible for disease development. Researchers may use one of several approaches for correcting faulty genes:
https://www.sciencedirect.com/science/article/pii/S0167779916302323
Gene Therapy for Treating Gene-Associated Human Diseases. Rapid progress in molecular biology and the completion of the human genome project have shown that gene therapy is a promising approach for treating gene-associated human diseases such as cancer, to which a high rate of patients succumb under standard treatments of chemotherapy, radiotherapy, and surgery .Author: Joanna K.L. Wong, Rashin Mohseni, Amir Ali Hamidieh, Robert E. MacLaren, Nagy Habib, Alexander M. Se...
https://www.nature.com/articles/s41565-019-0382-5
High aspect ratio nanomaterials enable efficient delivery of DNA into mature plant cells in a species-independent and non-integrating manner for plant genetic engineering applications.Author: Gozde S. Demirer, Huan Zhang, Juliana L. Matos, Natalie S. Goh, Francis J. Cunningham, Younghun Sung...
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(16)30232-3
The high mortality rates of cancer patients receiving standard treatments emphasize the crucial need for alternative treatments. One promising strategy is to use organic nanoparticles (NPs) for gene delivery. Although multifunctional NPs theoretically have many desirable properties as gene vectors, there are several practical barriers to successful gene delivery. In this review we discuss the ...Author: Joanna K.L. Wong, Rashin Mohseni, Amir Ali Hamidieh, Robert E. MacLaren, Nagy Habib, Alexander M. Se...
https://www.touchophthalmology.com/nanotechnology-for-gene-delivery-to-the-eye/
Nanotechnology-based gene delivery systems offer a wide range of possibilities for gene delivery to the eye. In comparison with viral vectors, the non-viral vectors offer greater flexibility in customising the system for the purpose of targeting or enhancing the in vivo circulation time. The choice of route of administration should be governed ...
https://www.nanowerk.com/nanotechnology-news2/newsid=54326.php
In their study in the journal Nanomedicine: Nanotechnology, Biology and Medicine ("Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies"), the researchers caution that for safety and biological reasons, it is unlikely that the suicide gene herpes simplex virus type I thymidine kinase (HSVtk) — which makes tumor ...
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