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https://www.sciencedirect.com/science/article/pii/S1773224712500109
Several studies have highlighted the potential of local pulmonary delivery of siRNAs for the treatment of lung diseases. For this purpose, nanoscale delivery systems were addressed to target passively or actively the target cell. This review discusses the possibilities of approaching lung delivery of nanoscale particles carrying siRNAs.Author: T.L. Nascimento, H. Hillaireau, E. Fattal
https://www.researchgate.net/publication/280717103_Nanoscale_Particles_for_Lung_Delivery_of_siRNA
Nanoscale Particles for Lung Delivery of siRNA Article in Journal of Drug Delivery Science and Technology 22(1):99-108 · December 2012 with 11 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low .Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443240/
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America, 111, 3955–3960. [PMC free article] [Google Scholar] Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, … Danielsen M (1987).Author: Bin Li, Xinfu Zhang, Yizhou Dong
https://www.researchgate.net/publication/262928803_siRNA_Delivery_to_the_lung_What's_new
siRNA Delivery to the lung: What's new? ... This is often achieved by packing the siRNA in particles or liposomes in the nanoscale. However, many siRNA delivery systems that incorporate their ...
https://pubs.acs.org/doi/abs/10.1021/mp800136v
Mar 06, 2009 · Nanoscale Particles for Lung Delivery of siRNA. Journal of Drug Delivery Science and Technology 2012, 22 (1) , 99-108. DOI: 10.1016/S1773-2247(12)50010-9. Cui Zheng, Lin Niu, Jingjing Yan, Jie Liu, Ying Luo, Dehai Liang.Author: Yunching Chen, Joyeeta Sen, Surendar Reddy Bathula, Qi Yang, Raffaella Fittipaldi, Leaf Huang
https://www.jstage.jst.go.jp/article/kona/33/0/33_2016014/_html
Aerosol siRNA delivery to the lungs. (A) pulmonary delivery of naked or siRNA nanocarriers, (B) Carrier-based delivery of siRNA cellular uptake. The aerosolized formulation of siRNA and use of appropriate device delivers siRNA by inhalation, intratracheal, or intranasal delivery to the human or animal lung.Author: Susanne R. Youngren-Ortiz, Nishant S. Gandhi, Laura España-Serrano, Mahavir B. Chougule, Mahavir B. ...
https://pubs.rsc.org/en/content/articlelanding/2016/nr/c5nr06246b#!
A new general route for siRNA delivery is presented combining porous core–shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core–shell surface chemistry was in
https://www.nature.com/articles/aps201734
May 01, 2017 · Lung cancer is the second most prevalent and the deadliest among all cancer types. Chemotherapy is recommended for lung cancers to control tumor growth and …Author: Sharad Mangal, Wei Gao, Tonglei Li, Qi (Tony) Zhou
https://pubs.rsc.org/en/content/articlehtml/2015/nr/c4nr03962a
This delivery method was chosen for multiple reasons: not only are the nanoparticles spatially contained within the lungs, but intubation is a clinically relevant delivery method that results in longer lung retention of the delivered therapeutic compared to systemic delivery. 47 Though we've chosen to model delivery to breast cancer lung ...Author: Ryan A. Ortega, Whitney J. Barham, Bharat Kumar, Oleg Tikhomirov, Ian D. McFadden, Fiona E. Yull, To...
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