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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013600/
Apr 08, 2014 · Nanoparticle-Mediated Pulmonary Drug Delivery: A Review 1. Introduction. Lungs are an attractive target for the pulmonary administration... 2. Anatomy and Physiology of the Lungs. Lungs are responsible for the gas exchange and supply... 3. Nanoparticle-Based Systems for Pulmonary Application. 4. ...Author: Mukta Paranjpe, Christel C. Müller-Goymann
https://link.springer.com/chapter/10.1007/978-1-4419-9745-6_15
May 25, 2011 · This chapter aims to provide a rational for the use of nanoparticles in pulmonary delivery as well as an overview of strategies and physiological implications of nanoparticle delivery to the lungs. Formulation aspects of nanoparticle systems in the form of liquid dispersions and inhaled dry powders are also reviewed.Author: Alan B. Watts, Robert O. Williams
https://www.researchgate.net/publication/226597070_Nanoparticles_for_Pulmonary_Delivery
This chapter aims to provide a rational for the use of nanoparticles in pulmonary delivery as well as an overview of strategies and physiological implications of nanoparticle delivery to the lungs. Formulation aspects of nanoparticle systems in the form of liquid dispersions and inhaled dry powders are also...
https://www.nature.com/articles/aps201734
May 01, 2017 · There are a few challenges for the pulmonary delivery of nanoparticles, largely stemming from their extremely low mass and cohesive nature. Only the fraction of drug liberated from nanoparticles is...Author: Sharad Mangal, Wei Gao, Tonglei Li, Qi (Tony) Zhou
https://onlinelibrary.wiley.com/doi/abs/10.1002/med.20140
Methods are also being investigated to produce nanoparticles with properties suitable for improving access to the peripheral lung. Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and solvent extraction have been employed to produce nanoparticle formulations for pulmonary delivery.Author: Mark M. Bailey, Cory J. Berkland
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(07)00270-3.pdf
nanoparticles with bound paclitaxel used for cancer therapy, became available in 2005. Nanoparticle drug delivery to the lungs The pulmonary delivery of therapeutic nanoparticles has been explored for systemic and local applications of a variety of molecules (Table 1). Advantages of nanoparticle drug delivery
https://erj.ersjournals.com/content/erj/44/3/765.full.pdf
Polymeric particles have also been extensively studied for the delivery of pulmonary medicines; these include asthmatic drugs [9, 10], anti-tuberculosis drugs [11] and anti-cancer drugs [12, 13]. Many types of liposomal nano-formulations have been investigated for their drug delivery properties as well.Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
https://www.researchgate.net/publication/316975320_Pulmonary_delivery_of_nanoparticle_chemotherapy_for_the_treatment_of_lung_cancers_Challenges_and_opportunities
Pulmonary delivery, for example, can be used for both systemic and local delivery of nanomedicine; however, unique clearance mechanisms are encountered. The inhalation of nanoparticles results in...
https://www.sciencedirect.com/science/article/pii/S0378517316301247
Most attempts to achieve sustained drug delivery to pulmonary tissues using nanoparticles have focused on mucoadhesive particles (MAP). However, MAP become trapped in the luminal mucus layer and, as a result, are largely eliminated from the respiratory tract by mucociliary escalator and expiratory clearance, which undermines their sustained release potential.Author: Alexey Popov, Lisa Schopf, James Bourassa, Hongming Chen
https://www.sciencedirect.com/science/article/pii/S0168365918307077
Moreover, pulmonary delivery of drugs via nanoparticles has been proved to be efficacious due to their abilities to control drug release, improve the drug efficacy, decrease the dosing frequency, and increase the patient compliance [, , , ]. There are many different drug nanocarriers for pulmonary delivery, such as polymeric nanocarriers, lipid nanocarriers, hybrid lipid-polymer nanoparticles, and inorganic …Author: Caina Xu, Yanbing Wang, Zhaopei Guo, Jie Chen, Lin Lin, Jiayan Wu, Huayu Tian, Xuesi Chen
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