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https://www.sciencedirect.com/science/article/pii/S0378517309004128
This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS.Author: Alpesh Mistry, Snjezana Stolnik, Lisbeth Illum
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Olanzapine, when loaded onto PLGA nanoparticles, resulted in delivery to the brain that was 10 times more efficient than nose-to-brain delivery with olanzapine solution, resulting in a C max of 0.049% of the dose and a C max of 0.0045% of the dose with the nanoparticle and solution formulations, respectively (Seju et al., 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674633/
Feb 21, 2015 · Nose-to-brain delivery of drugs has attracted a lot of attention as a potential route of drug delivery to the brain as it bypasses first-pass metabolism and prevents enzymatic/chemical degradation of drugs. Being noninvasive in nature, nasal route provides an alternative to injectable formulations and enhances patient compliance.Author: Deepak Sharma, Rakesh Kumar Sharma, Navneet Sharma, Reema Gabrani, Sanjeev K. Sharma, Javed Ali, Shw...
https://www.sciencedirect.com/science/article/pii/B978012814001700010X
4. Nanoparticle systems for nose-to-brain delivery. Nanoparticles may improve the nose-to-brain drug delivery since they are able to protect the encapsulated drugs from biological and/or chemical degradation and increase their penetration across biological barriers.Author: Qingfeng Liu, Qizhi Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629108/
Nov 21, 2014 · In the present study, haloperidol (HP)-loaded solid lipid nanoparticles (SLNs) were prepared to enhance the uptake of HP to brain via intranasal (i.n.) delivery. SLNs were prepared by a modified emulsification–diffusion technique and evaluated for particle size, zeta potential, drug entrapment efficiency, in vitro drug release, and stability. All parameters were found to be in an …Author: Mohd Yasir, Udai Vir Singh Sara
https://hscweb3.hsc.usf.edu/blog/2019/12/04/nose-to-brain-delivery-of-nanoparticles-lowers-huntingtons-disease-gene-expression/
Nose-to-brain delivery of nanoparticles lowers Huntington’s disease gene expression. Written by Anne DeLotto Baier · December 4, 2019 @ 1:49 pm · Filed under College of Pharmacy, Hot News, Morsani College of Medicine, Neurosciences & Brain Repair, Research, USF Health Lead Story.
https://www.mdpi.com/1999-4923/10/1/34/htm
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects. Recently, nasal administration of insulin showed promising results in clinical trials ...Author: Fabio Sonvico, Adryana Rocha Clementino, Francesca Buttini, Gaia Colombo, Silvia Pescina, Silvia Sta...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00088
Chitosan and chitosan coating nanoparticles for the treatment of brain disease. International Journal of Pharmaceutics 2019, 560, 282-293. DOI: 10.1016/j.ijpharm.2019.02.012. Teresa Musumeci, Angela Bonaccorso, Giovanni Puglisi. Epilepsy Disease and Nose …Author: Alpesh Mistry, Snjezana Stolnik, Lisbeth Illum
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects.
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