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https://www.sciencedirect.com/science/article/pii/S0378517309004128
This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS. This is relevant in the field of drug delivery as well as for new developments in nanotechnology.Author: Alpesh Mistry, Snjezana Stolnik, Lisbeth Illum
https://www.sciencedirect.com/science/article/pii/B978012814001700010X
Nanoparticles may improve the nose-to-brain drug delivery since they are able to protect the encapsulated drugs from biological and/or chemical degradation and increase their penetration across biological barriers.Author: Qingfeng Liu, Qizhi Zhang
https://www.ncbi.nlm.nih.gov/pubmed/26996366
METHODS: Nanoparticles being smaller in size and large surface area help in increasing the rate of drug permeation to the brain. In this review work, emphasis has been laid on discussion on various works done in the field of nasal delivery of drugs to brain over the last decade.Author: Kunjan Phukan, Marika Nandy, Rupanjali B. Sharma, Hemanta K. Sharma
https://www.ncbi.nlm.nih.gov/pubmed/25039773
The delivery of drugs to the brain via the nose-to-brain route holds great promise, on the basis of preclinical research by means of drug delivery systems such as polymeric nanoparticles and clinical data related to intranasal delivery to CNS of large molecular weight biologics administered in solution, but safety issues about toxicity on nasal mucosa, Np transport into the brain, delivery only to specific brain …Author: Wei-Yi Ong, Suku-Maran Shalini, Luca Costantino
https://www.pharmatutor.org/articles/direct-nose-to-brain-delivery-drugs-nanoparticulate-approach-review
Polymeric nanoparticles based on biodegradable polymers have been extensively studied as they offer improvement in nose-to-brain drug delivery by protecting the encapsulated drug from biological and/or chemical degradation and extra cellular transport by P-gp efflux system.
https://www.mdpi.com/1999-4923/11/2/84/pdf
The easiest classification of NEs designed for nose-to-brain delivery is based on the drug loaded and the therapeutic purpose. As the final target is the brain through the nose, the pharmacological actions regard pathologies of the CNS. In one case, a probe is loaded in the NE to obtain brain imaging.Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.researchgate.net/publication/257221748_Mistry_A_Stolnik_S_and_Illum_L_Nanoparticles_for_direct_nose-to-brain_delivery_of_drugs_Int_J_Pharm_379_146-157
This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS. This is relevant in the field of drug delivery …
https://www.precisionnanosystems.com/resource-center/publications/detail/nose-to-brain-delivery-of-enveloped-rna---cell-permeating-peptide-nanocomplexes-for-the-treatment-of-neurodegenerative-diseases
Abstract. Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while minimizing systemic exposure. The objective of this work was to engineer a nanocarrier intended to enhance N-to-B delivery of RNA and to explore its potential utility for the treatment of …
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Olanzapine, when loaded onto PLGA nanoparticles, resulted in delivery to the brain that was 10 times more efficient than nose-to-brain delivery with olanzapine solution, resulting in a C max of 0.049% of the dose and a C max of 0.0045% of the dose with the nanoparticle and solution formulations, respectively (Seju et al., 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
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