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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323692/
May 15, 2012 · Currently, there are two polymeric nanoparticle drug delivery systems on the market for non-CNS applications: 1) Abraxane®, an albumin-based nanoparticle loaded with paclitaxel and used in the treatment for breast cancer and 2) Abdoscan®, an iron oxide and dextran-based nanoparticle used for diagnostic imaging of the liver and spleen.Author: Toral Patel, Jiangbing Zhou, Joseph M. Piepmeier, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474019/
Mar 05, 2019 · A classic example of drug that enters the CNS by this mechanism is the L-DOPA or Levodopa anti-Parkinson drug, which operates with large amino acid transporter 1 (LAT-1) . The same mechanism elucidates how glucose, vitamins and some peptides can cross the brain at a faster rate than would be expected, centered on both their physical and chemical characteristics [ 57 ].Author: Daniel Mihai Teleanu, Irina Negut, Valentina Grumezescu, Alexandru Mihai Grumezescu, Raluca Ioana Te...
https://www.sciencedirect.com/science/article/pii/S1773224719315424
Contrary to this, Nanoparticle mediated drug delivery is a relatively mitigatory method and transports the drug across BBB without any damage to the BBB [, , ]. These nanoparticle drug delivery systems provide massive advantages regarding drug targeting, delivery, and release.
https://www.ncbi.nlm.nih.gov/pubmed/19341816
Recently we discovered that polymeric nanoparticles (NPs) made of poly(D,L-lactide-co-glycolide), surface-decorated with the peptide Gly-L-Phe-D-Thr-Gly-L-Phe-L-Leu-L-Ser(O-beta-D-glucose)-CONH2 are able to deliver, after intravenous administration, the model drug loperamide into the central nervous system (CNS). This new drug delivery agent is able to ensure a strong and long-lasting …Author: Anna Valeria Vergoni, Giovanni Tosi, Raffaella Tacchi, Maria Angela Vandelli, Alfio Bertolini, Luca ...
https://www.sciencedirect.com/science/article/pii/S0014305719324978
Nanoparticle systems based on carbohydrate polymers have received much attention for drug delivery in recent decades. Drug delivery to CNS is one of the significant challenges in this field. The applications of various types of carbohydrate polymer in drug delivery to the brain were highlighted in …Author: Ramin Ansari, Seyed Mahdi Sadati, Negin Mozafari, Hajar Ashrafi, Amir Azadi
https://www.sciencedirect.com/science/article/pii/S0168365916303236
Nanoparticles (NPs) are considered one of the most auspicious and versatile drug delivery systems into inaccessible regions like the brain, being able to provide protection to therapeutic agents while efficiently delivering them into the damaged areas.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392984/
May 21, 2013 · To obtain insight into the properties of drug delivery vehicles that direct their intracellular processing in brain endothelial cells, the intracellular traffic of fixed-size nanoparticles in an in vitro BBB model as a function of distinct nanoparticle surface modifications has been investigated.Author: Massimo Masserini
https://www.sciencedirect.com/science/article/pii/S0165247817301761
The first, inhibition of drug delivery to healthy non-cancer cells and the second, the direct conduction of drugs into tumor site. Nanoparticles (NPs) are the new identified tools by which we can deliver drugs into tumor cells with minimum drug leakage into normal cells.Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier …Author: Wim H De Jong, Paul Ja Borm
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