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https://www.ncbi.nlm.nih.gov/pubmed/19488722
Nonviral gene delivery has been gaining considerable attention recently. Although the efficacy of DNA transfection, which is a major concern, is low in nonviral vector-mediated gene transfer compared with viral ones, nonviral vectors are relatively easy to prepare, less immunogenic and oncogenic, and have no potential of virus recombination and no limitation on the size of a transferred gene.Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480422/
Mar 13, 2017 · Taken together, these findings indicate that HA is an important targeted delivery ligand for polymer nanoparticle-mediated gene delivery toward CD44-expressing lung cancers. Transferrin The TfR monomer contains a large extracellular C-terminal domain, a single-pass transmembrane domain, and a short intracellular N-terminal domain.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
https://www.ncbi.nlm.nih.gov/pubmed/18679632
Nanoparticle-mediated gene delivery to the lung. Ramesh R(1). Author information: (1)Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D.Anderson Cancer Center, Houston, TX, USA. Drug delivery, especially gene delivery to the lung, has been a challenge.Author: Rajagopal Ramesh
https://link.springer.com/protocol/10.1007%2F978-1-59745-483-4_34
May 07, 2009 · Summary. Nonviral gene delivery has been gaining considerable attention recently. Although the efficacy of DNA transfection, which is a major concern, is low in nonviral vector-mediated gene transfer compared with viral ones, nonviral vectors are relatively easy to prepare, less immunogenic and oncogenic, and have no potential...Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.ncbi.nlm.nih.gov/pubmed/28290155
Receptor-targeted delivery is a promising approach that can limit non-specific gene delivery and can be achieved by modifying the polymer nanoparticle surface with specific receptor ligands or antibodies.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
https://www.nature.com/articles/gt201195
Jun 23, 2011 · Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes Skip to main content Thank you for visiting nature.com.Author: Kim Ey, Schulz R, Swantek P, Kunstman K, Malim Mh, Wolinsky Sm
https://www.worldscientific.com/doi/abs/10.1142/S1793984412430015
Magnetic nanoparticles (MNPs) have emerged as a major platform for the formulation of magnetic vectors for nonviral gene delivery. Notably the application of "magnetofection" strategies (use of magnetic fields to increase MNP–cell interactions) can significantly enhance MNP mediated gene transfer.
https://www.sciencedirect.com/science/article/pii/S0167779918300933
Key Figure: Nanoparticle (NP)-Mediated Genetic Cargo Delivery to Animals and Plants. (A) NPs commonly used for biomolecule delivery in both animal and plant systems cover five major categories: bio-inspired, carbon-based, silicon-based, polymeric, and metallic/magnetic.Author: Francis J. Cunningham, Natalie S. Goh, Gozde S. Demirer, Juliana L. Matos, Markita P. Landry
http://web.ics.purdue.edu/~jfleary/nanomedicine_course_2011/Lecture_10%20Gene%20Delivery/References/Jin%20and%20Ye%20Biotechnol%20Prog%202007.pdf
drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering capability into disease therapy will provide constant and concentrated drug
https://www.nature.com/articles/am2017185
Oct 27, 2017 · Because of the powerful gene-editing ability of the CRISPR/Cas9 system and the excellent gene delivery capability of the PLNPs, we believe that …Author: Lingmin Zhang, Lingmin Zhang, Peng Wang, Qiang Feng, Nuoxin Wang, Zitian Chen, Yanyi Huang, Wenfu Zh...
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