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https://www.sciencedirect.com/science/article/pii/S0168365916303236
Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases. ... NPs are exciting systems for brain drug delivery due to the possibility to modulate them in terms of shape, size, hydrophobicity, coating, chemistry and surface charge.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Nanoparticles and drug delivery. Drug delivery and related pharmaceutical development in the context of nanomedicine should be viewed as science and technology of nanometer scale complex systems (10–1000 nm), consisting of at least two components, one of which is a pharmaceutically active ingredient (Duncan 2003; Ferrari 2005), although nanoparticle formulations of the drug itself are also ...Author: Wim H De Jong, Paul Ja Borm
https://www.ncbi.nlm.nih.gov/pubmed/27208862
Aug 10, 2016 · Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. Saraiva C(1), Praça C(2), Ferreira R(1), Santos T(1), Ferreira L(3), Bernardino L(4). Author information: (1)Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.hindawi.com/journals/isrn/2013/238428/
As a consequence, several strategies are currently being sought after to enhance the delivery of drugs across the BBB. Within this review, the recently born strategy of brain drug delivery based on the use of nanoparticles, multifunctional drug delivery systems with size in …Author: Massimo Masserini
https://www.hopkinsmedicine.org/news/media/releases/improved_nanoparticles_deliver_drugs_into_brain
Sep 11, 2012 · The brain is a notoriously difficult organ to treat, but Johns Hopkins researchers report they are one step closer to having a drug-delivery system flexible enough to overcome some key challenges posed by brain cancer and perhaps other maladies affecting that organ. In a report published online on August 29 in Science Translational Medicine, the Johns Hopkins team says its bioengineers …
https://www.sciencedirect.com/science/article/pii/S2211383516301186
Thus an ideal brain targeting drug delivery system should possess two characteristics: (1) effective penetration of the BBB or bypassing BBB, (2) selectively targeting diseased cells while minimizing the distribution into normal brain cells. To achieve these two goals, dual …Author: Huile Gao
https://www.sbir.gov/node/1413695
Therapies to treat traumatic brain injury have failed to translate from the bench to the bedside. Poor blood brain barrier (BBB) penetration of drugs poses a substantial hurdle to overcome. Nanotechnology-based delivery systems offer a novel drug delivery platform that will allow successful delivery of drug molecules in a controlled manner (1).
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