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https://medicalxpress.com/news/2019-04-gold-nanoparticle-delivery-microrna-impairs.html
Apr 12, 2019 · Gold nanoparticle delivery of microRNA impairs metastasis in triple-negative breast cancer Weill Cornell Medicine researchers have shown …
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02578
MiRNA-21 mimic was delivered to cardiac macrophages post MI by nanoparticles (NPs), spontaneously assembled due to the complexation of hyaluronan-sulfate with the nucleic acid mediated by calcium ion bridges, yielding slightly anionic NPs with a mean diameter of 130 nm.
https://medicalxpress.com/news/2019-04-gold-nanoparticle-delivery-microrna-impairs.html
Apr 12, 2019 · Weill Cornell Medicine researchers have shown that giving mice with triple-negative breast cancer therapeutic microRNA (miRNA) in a protective gold nanoparticle results in significantly less ...
https://pubs.acs.org/doi/suppl/10.1021/acs.nanolett.8b02578/suppl_file/nl8b02578_si_001.pdf
Nanoparticle Delivery of miRNA-21 mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction Tzlil Bejerano1, Sharon Etzion2, Sigal Elyagon2,3, Yoram Etzion2,3, Smadar Cohen1,2,4 * 1Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion
https://www.mdpi.com/2073-4409/9/2/521/htm
Bacterial minicells are a relatively new nanoparticle delivery system, with currently one pre-clinical study using bacterial minicells for delivery of a tumor suppressor miRNA. This has, however, progressed to clinical trial. MiR-16 is significantly downregulated in MPM compared to healthy controls .
https://mirnablog.com/microrna-delivery-by-nanoparticles/
Two groups have recently published results of microRNA delivery by nanoparticles. The first group, at University of California San Diego 1, identified miR-132 as a highly upregulated miRNA in a human embryonic stem cell model of vasculogenesis and showed that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducing …
https://www.researchgate.net/publication/312545308_Nanoparticle_Based_Delivery_of_miRNAs_to_Overcome_Drug_Resistance_in_Breast_Cancer
Nanoparticle-based targeted drug delivery is a successful strategy to overcome the side effect of chemotherapy. Nanoparticles based drug delivery systems that have been designed to enhance ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-7138-1_14
Jul 21, 2017 · To overcome challenges with in vivo delivery of microRNAs related to stability, cellular uptake, and specific delivery, our group has developed and characterized chitosan nanoparticles for nucleotide delivery. This platform allows for robust target modulation and antitumor activity following intravenous administration.
https://www.mdpi.com/2073-4409/9/2/521/pdf
Tumor suppressor miRNA encapsulation in nanoparticle formulations for delivery to primary tumors and metastases (image created usingBiorender.com—paid subscription). The ideal nanoparticle delivery vehicle should be safe and well-tolerated, have tumor-targeting
https://www.nature.com/articles/s41598-020-62269-4
Mar 24, 2020 · The theranostic nanodrug consisted of magnetic nanoparticles (MN) used for delivery of miRNA mimics (MN-miRNA) or inhibiting locked nucleic …
https://www.pnas.org/content/109/26/E1695
Jun 26, 2012 · Nanoparticle delivery of anti-miR-155 PNAs inhibits miR-155 in vitro. (A) miR-155 dual luciferase sensor demonstrates feasibility of nanoparticle-mediated anti-miR delivery to Toledo B cells (n = 3, data represented as mean ± SD); t test was used for statistical analysis
https://www.nature.com/articles/s41598-018-36910-2
Jan 24, 2019 · Specific LNP formulations can be internalized by platelets. The amount of mRNA delivered to platelets by four different classes of lipid nanoparticles (LNPs) was …
https://link.springer.com/article/10.1007%2Fs12551-017-0392-1
Jan 11, 2018 · We discuss the advantages and disadvantages of the various types of nanoparticle delivery systems, with a focus on those that have been investigated in breast cancer in vivo. Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer SpringerLink
https://mdanderson.elsevierpure.com/en/publications/chitosan-nanoparticles-for-mirna-delivery
To overcome challenges with in vivo delivery of microRNAs related to stability, cellular uptake, and specific delivery, our group has developed and characterized chitosan nanoparticles for nucleotide delivery. This platform allows for robust target modulation and antitumor activity following intravenous administration. KW - Chitosan nanoparticles
https://www.researchgate.net/publication/339496838_Nanoparticle-Based_Delivery_of_Tumor_Suppressor_microRNA_for_Cancer_Therapy
Tumor Suppressor miRNA Delivery Via Lipid-Based Nanoparticles . ... lipid-nanoparticle delivery of synthetic miR-660 had no immunological off-target or acute/chronic toxic effects on ...
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