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https://www.researchgate.net/publication/42832517_Nanoparticle-Based_Delivery_System_for_Application_of_siRNA_In_Vivo
Nanoparticle-Based Delivery System for Application of siRNA In Vivo Article · Literature Review in Current Drug Metabolism 11(2):182-96 · March 2010 with 63 Reads How we measure 'reads'
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=11&issue=2&spage=182
One of the most important issues to overcome before full clinical application is the development of effective administration methods for siRNAs to the target tissue or cells in vivo, which is highly dependent on the delivery system. Currently, there are two major kinds of in vivo …
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been ...Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://ieeexplore.ieee.org/document/7784799/
Dec 15, 2016 · Small interfering RNA (siRNA) is an important RNAi tool that has found significant application in cancer therapy. However due to lack of stability, poor cellular uptake and high probability of loss-of-function due to degradation, siRNA therapeutic strategies seek safe and efficient delivery vehicles for in vivo applications.Author: Anish Babu, Ranganayaki Muralidharan, Narsireddy Amreddy, Meghna Mehta, Anupama Munshi, Rajagopal Ra...
https://altogen.com/product/nanoparticle-in-vivo-transfection-reagent/
Altogen Biosystems provides in vivo transfection reagents, over 100 pre-optimized in vitro transfection kits for cell lines and primary cells, and electroporation delivery products. Transfection reagents are highly efficient for DNA and siRNA transfection in vivo and in vitro. Altogen CRO offers in vivo RNAi services, tumor xenograft models, toxicology testing, stable cell line generation, and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/
Apr 06, 2016 · Nanoparticle-based delivery system for application of siRNA in vivo. Curr Drug Metab 11: 182–196. Davis, ME (2009). The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm 6: 659–668.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.hindawi.com/journals/bmri/2013/782041/
Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
http://www.cell-transfection.com/home-2/cell-biology/molecular-biology/nanoparticle-based-transfection-reagents/
Specific transfection reagents are used for different types of cells in vitro. In vivo nanoparticle-based transfection reagents have been recently developed for delivery of DNA, siRNA and microRNA molecules to xenograft animal models.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418108/
Current limitations of nanoparticle-siRNA delivery. Nanoparticle-based drug delivery still has some limitations, and the barriers and obstacles encountered by nanoparticle-siRNA complexes are schematized in Figure 3 (adapted from Whitehead50). First …
https://www.sciencedirect.com/science/article/pii/S2329050116301656
Production and clinical development of nanoparticles for gene delivery. ... Biodegradation is the primary factor for the clinical application of nanoparticle-based gene delivery. 21 Poly ... LH Liang, A JiNanoparticle-based delivery system for application of siRNA in vivo…Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
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