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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649006/
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems.Author: Jiehua Zhou, Ka To Shum, John C. Burnett, John J. Rossi
https://www.mdpi.com/1424-8247/6/1/85/htm
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems. Inspired by the immense progress with ...Author: Jiehua Zhou, Ka To Shum, John C. Burnett, John J. Rossi
https://www.researchgate.net/publication/236693091_Nanoparticle-Based_Delivery_of_RNAi_Therapeutics_Progress_and_Challenges
Jan 16, 2013 · Inspired by the immense progress with nanotechnology in drug delivery, efforts have been dedicated to the development of nanoparticle-based RNAi delivery systems.
http://www.oalib.com/paper/2261253
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems.
https://core.ac.uk/display/120609677
Abstract. RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems.
https://www.hindawi.com/journals/bmri/2013/782041/
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that enables sequence-specific gene silencing by promoting degradation of specific mRNAs. Molecular therapy using small interfering RNA (siRNA) has shown great therapeutic potential for diseases caused by abnormal gene overexpression or mutation. The major challenges to application of siRNA therapeutics include ...Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://www.genengnews.com/uncategorized/rnai-therapeutics-to-the-liver-and-beyond/
Mar 14, 2018 · RNAi Therapeutics: To the Liver … and Beyond. RNAi Therapy Components Are Surviving Degradation, Staying Potent, and Reaching More Targets Than Ever
https://link.springer.com/article/10.1208/s12248-018-0267-9
Oct 10, 2018 · The recent progress in harnessing the efficient and precise method of DNA editing provided by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy. However, the development of safe and optimally efficient delivery systems for CRISPR/Cas9 elements capable of achieving specific targeting of gene therapy to the location of interest without off-target …Author: Brittany E. Givens, Youssef W. Naguib, Youssef W. Naguib, Sean M. Geary, Eric J. Devor, Aliasger K. ...
https://www.nature.com/articles/nbt.3078
Nov 17, 2014 · Neutralizing the RNA phosphodiester backbone enables delivery of siRNA across cell membranes. RNA interference (RNAi) has great potential to treat human disease1,2,3. However, in …Author: Bryan R Meade, Khirud Gogoi, Alexander S Hamil, Caroline Palm-Apergi, Arjen van den Berg, Jonathan C...
https://www.ncbi.nlm.nih.gov/pubmed/26735861
Progress and perspective of inorganic nanoparticle-based siRNA delivery systems. ... even "undruggable" ones that are nearly impossible to target through traditional small molecule therapeutics. Delivery to the cell and then to the cytosol is the primary requirement for realization of therapeutic potential of siRNA. AREAS COVERED: We summarize ...Author: Ying Jiang, Shuaidong Huo, Joseph Hardie, Xing-Jie Liang, Vincent M. Rotello
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