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https://www.medgadget.com/2018/11/nanoneedle-skin-patch-to-inject-drugs-into-cells.html
This is because the nanoneedle arrays are normally placed on rigid silicon wafers. ... allowing for accurate and minimally invasive drug delivery straight into living cells. ...
https://www.sciencedirect.com/science/article/pii/B9780857097668500089
AFM actuation is the first strategy implemented for the use of silicon nanoneedles for drug delivery ().The force measurements with an AFM instrument can be used to study cellular events in individual cells with great sensitivity (Lamontagne et al., 2008).Among the applications is the injection at the nanoscale of specific molecular entities in individual living cells.Author: C. Chiappini, C. Almeida
https://en.wikipedia.org/wiki/Drug_delivery
Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.
https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1304409
Dec 23, 2014 · So there is a need for advanced drug delivery systems like microneedles and nanoneedles through transdermal route. These tiny needles will also serve as non-toxic, safe and stable systems for advanced drug delivery. Thus, macro to nanoformulation is the …Author: Pravin Shende, Mrunmayi Sardesai, R. S. Gaud
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
Drug delivery into the skin for local or systemic effects is extremely difficult due to the highly effective barrier properties of skin’s outer layer, the stratum corneum. The human stratum corneum is only 10 – 15 μm thick, but precludes absorption of most drugs at therapeutic levels .Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.nanowerk.com/spotlight/spotid=34383.php
Feb 13, 2014 · "Inspired by the success of employing microneedle arrays for drug delivery, we first reported using a nanoneedle array to actively and mechanically disrupt cell membranes for intracellular delivery," says Xianfeng Chen, an assistant professor at the …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036548/
Sep 21, 2016 · TiO 2 nanotube platforms for smart drug delivery: a review. ... The ultrasound-sensitive drug delivery based on applying the local ultrasonic field is expected to be a more reliable method compared with the magnetic-sensitive drug delivery that is uncontrollable in drug release when triggered by magnetic fields.Author: Qun Wang, Jian-Ying Huang, Hua-Qiong Li, Zhong Chen, Allan Zi-Jian Zhao, Yi Wang, Ke-Qin Zhang, Hong...
https://www.sciencedaily.com/releases/2009/04/090428124353.htm
May 06, 2009 · The delivery process can be precisely controlled, monitored and recorded – goals that have not been achieved in prior studies. "The nanoneedle provides …
https://www.researchgate.net/publication/326100386_Micro_and_nanoneedles_for_drug_delivery_and_biosensing
Micro and nanoneedle-based biosensing also poses potential for environment-responsive drug delivery. ... A number of other drug delivery systems which vary in structure and compositions, such as ...
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