Nanocapsules For Protein Delivery

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A novel intracellular protein delivery platform based on ...

    http://www.nature.com/articles/nnano.2009.341
    Nov 22, 2009 · Here, we show a novel delivery platform based on nanocapsules consisting of a protein core and a thin permeable polymeric shell that can be engineered to either degrade or remain stable at ...

Breakable Hybrid Organosilica Nanocapsules for Protein ...

    https://www.onlinelibrary.wiley.com/doi/abs/10.1002/anie.201508288
    The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself.

Protein Delivery Segura Lab

    https://segura.pratt.duke.edu/research/protein-delivery
    The effect of this process is the polymerization of a polymeric network around the protein. By controlling the concentration of the protein, monomers and crosslinker, nanoparticles (nanocapsules) can be generated that are stable at physiological conditions.

A novel intracellular protein delivery platform based on ...

    https://www.researchgate.net/profile/Zheng_Liu14/publication/40028951_A_novel_intracellular_protein_delivery_platform_based_on_single-protein_nanocapsules/links/541a5e330cf2218008bfb232.pdf
    A novel intracellular protein delivery platform based on single-protein nanocapsules Ming Yan1†,JuanjuanDu1†,ZhenGu1, Min Liang2, Yufang Hu3, Wenjun Zhang1, Saul …

(PDF) Nanostructures for protein drug delivery

    https://www.researchgate.net/publication/284171142_Nanostructures_for_protein_drug_delivery
    Nanostructures for protein drug delivery. ... single-protein nanocapsules and hydrogel nanoparticles has been a challenge, especially to allow for protein stabilization [29]. In this study, the ...

Endoprotease-Mediated Intracellular Protein Delivery Using ...

    https://fan.genetics.ucla.edu/papers/nn1031005.pdf
    nanocapsules. In vitro cell culture studies demonstrated successful intracellular delivery of both nuclear and cytosolic proteins and confirmed the importance of furin-degradable construction for native protein release. This endoprotease-mediated intracellular delivery system may be extended to effectively deliver various biological therapeutics.

Controlled Protein Delivery Based on Enzyme-Responsive ...

    http://europepmc.org/articles/PMC3263975
    This study suggests that using protein nanocapsules rather than native ones can effectively reduce leaching of the protein from the hydrogels. In conclusion, we have demonstrated a novel class of protein nanocapsules that can release the encapsulated proteins with …

Layer-by-layer assembled polyaspartamide nanocapsules for ...

    https://pubag.nal.usda.gov/catalog/957311
    Bovine serum albumin (BSA), as a model protein, was entrapped in the nanocapsules via electrostatic adsorption. Nanocapsules encapsulating BSA were prepared via layer-by-layer assembly on protein-entrapping amino-functionalized silica spheres, hydrazone cross-linking and silica core removal. The BSA release profiles exhibited a pH-dependent ...

An intracellular protein delivery platform based on ...

    https://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc05099a
    An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to

Intracellular Trafficking Network of Protein Nanocapsules ...

    http://www.thno.org/v06p2099.htm
    Protein nanocapsules must enter the cytoplasm to execute their function, particularly the protein molecules. However, the cellular trafficking of the protein nanocapsules will transport them to lysosomes for degradation from endocytosis and autophagy.

Redox-Responsive Nanocapsules for Intracellular Protein ...

    https://escholarship.org/uc/item/6d4337c9
    A novel strategy using polymeric redox-responsive nanocapsules for intracellular protein delivery is described, in which through in situ interfacial polymerization, the target therapeutic protein is noncovalently encapsulated into a biocompatible polymeric …

Polyethylene glycol-based protein nanocapsules for ...

    https://fan.genetics.ucla.edu/papers/1-s2.0-S0142961212004097-main.pdf
    Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor Anuradha Biswasa,c, Ying Liud, Tianfei Liua, Guoping Fand,**, Yi Tanga,b,c,* aDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA b Department of Chemistry and Biochemistry, University of California at Los Angeles ...

WO2016183050A1 - Polymer nanocapsules for protein delivery ...

    https://patents.google.com/patent/WO2016183050A1/en
    A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of Formula (I) (I) wherein X, L1, R1, and y are as described herein. The nanocapsule further includes a core comprising an oil. A composition is also disclosed including a plurality of the nanocapsules dispersed in an aqueous solution.

Zhen Gu - Google Scholar Citations

    http://scholar.google.com/citations?user=RmSzz80AAAAJ&hl=en
    A novel intracellular protein delivery platform based on single-protein nanocapsules M Yan, J Du, Z Gu, M Liang, Y Hu, W Zhang, S Priceman, L Wu, ZH Zhou, ... Nature nanotechnology 5 (1), 48 , 2010

Redox Responsive Polymeric Nanocapsules for Protein ...

    https://www.ibridgenetwork.org/#!/profiles/5055150541011/innovations/391/
    iBridge.Network accelerates innovation by allowing you to discover and connect to game-changing technologies and technology professionals on the world's most comprehensive technology network.

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