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http://www.nature.com/articles/nnano.2009.341
Nov 22, 2009 · Here, we show a novel delivery platform based on nanocapsules consisting of a protein core and a thin permeable polymeric shell that can be engineered to either degrade or remain stable at ...
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/anie.201508288
The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself.
https://segura.pratt.duke.edu/research/protein-delivery
The effect of this process is the polymerization of a polymeric network around the protein. By controlling the concentration of the protein, monomers and crosslinker, nanoparticles (nanocapsules) can be generated that are stable at physiological conditions.
https://www.researchgate.net/profile/Zheng_Liu14/publication/40028951_A_novel_intracellular_protein_delivery_platform_based_on_single-protein_nanocapsules/links/541a5e330cf2218008bfb232.pdf
A novel intracellular protein delivery platform based on single-protein nanocapsules Ming Yan1†,JuanjuanDu1†,ZhenGu1, Min Liang2, Yufang Hu3, Wenjun Zhang1, Saul …
https://www.researchgate.net/publication/284171142_Nanostructures_for_protein_drug_delivery
Nanostructures for protein drug delivery. ... single-protein nanocapsules and hydrogel nanoparticles has been a challenge, especially to allow for protein stabilization [29]. In this study, the ...
https://fan.genetics.ucla.edu/papers/nn1031005.pdf
nanocapsules. In vitro cell culture studies demonstrated successful intracellular delivery of both nuclear and cytosolic proteins and confirmed the importance of furin-degradable construction for native protein release. This endoprotease-mediated intracellular delivery system may be extended to effectively deliver various biological therapeutics.
http://europepmc.org/articles/PMC3263975
This study suggests that using protein nanocapsules rather than native ones can effectively reduce leaching of the protein from the hydrogels. In conclusion, we have demonstrated a novel class of protein nanocapsules that can release the encapsulated proteins with …
https://pubag.nal.usda.gov/catalog/957311
Bovine serum albumin (BSA), as a model protein, was entrapped in the nanocapsules via electrostatic adsorption. Nanocapsules encapsulating BSA were prepared via layer-by-layer assembly on protein-entrapping amino-functionalized silica spheres, hydrazone cross-linking and silica core removal. The BSA release profiles exhibited a pH-dependent ...
https://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc05099a
An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to
http://www.thno.org/v06p2099.htm
Protein nanocapsules must enter the cytoplasm to execute their function, particularly the protein molecules. However, the cellular trafficking of the protein nanocapsules will transport them to lysosomes for degradation from endocytosis and autophagy.
https://escholarship.org/uc/item/6d4337c9
A novel strategy using polymeric redox-responsive nanocapsules for intracellular protein delivery is described, in which through in situ interfacial polymerization, the target therapeutic protein is noncovalently encapsulated into a biocompatible polymeric …
https://fan.genetics.ucla.edu/papers/1-s2.0-S0142961212004097-main.pdf
Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor Anuradha Biswasa,c, Ying Liud, Tianfei Liua, Guoping Fand,**, Yi Tanga,b,c,* aDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA b Department of Chemistry and Biochemistry, University of California at Los Angeles ...
https://patents.google.com/patent/WO2016183050A1/en
A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of Formula (I) (I) wherein X, L1, R1, and y are as described herein. The nanocapsule further includes a core comprising an oil. A composition is also disclosed including a plurality of the nanocapsules dispersed in an aqueous solution.
http://scholar.google.com/citations?user=RmSzz80AAAAJ&hl=en
A novel intracellular protein delivery platform based on single-protein nanocapsules M Yan, J Du, Z Gu, M Liang, Y Hu, W Zhang, S Priceman, L Wu, ZH Zhou, ... Nature nanotechnology 5 (1), 48 , 2010
https://www.ibridgenetwork.org/#!/profiles/5055150541011/innovations/391/
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