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http://www.thepharmajournal.com/vol1Issue11/Issue_jan_2013/1.1.pdf
The nail plate may appear abnormal as a result of decreased glow. It`s involvement of nail bed, reduction of blood supply, physical or chemical features of nail bed. As a result variety of diseases occurs. These diseases can be cured by achieving desired therapeutic concentration of drug by nail drug delivery system.
https://www.researchgate.net/publication/305488166_Nail_Drug_Delivery_System_A_Review
by nail drug delivery system. The human nail plate consists of three layers; the dorsal & intermediate layer derived from the matrix, & the ventral layer from nail bed.
https://www.researchgate.net/publication/255758355_NAIL_DRUG_DELIVERY_SYSTEM
A novel ultrasound mediated drug delivery system has been developed for the treatment of a nail fungal disorder (onychomycosis) by improving delivery to the nail bed using ultrasound to increase the permeability of the nail. The slip-in device consists of ultrasound transducers and drug delivery compartments...
http://www.pharmaresearchlibrary.com/review-on-nails-drug-delivery-system-recent-advances-and-marketed-products/
Nails drug delivery system (NDDS) is an important delivery system in mammals, in which their nails are highly affected by the fungal diseases. This review is to explore the difficulties in penetration of drug across nail plate & enhancement of bioavailability of antifungal drug.
http://ijpsr.com/bft-article/nail-as-a-promising-drug-delivery-system-for-controlled-release/?view=fulltext
Nail lacquers as Perungual Drug Delivery System: Nail lacquers (varnish, enamel) have been used as a cosmetic for a very long time to protect nails and for decorative purposes. Conventional nail lacquers generally consist of solvents, film forming polymers, resins, which increase the adhesion of the film to the nail plate, plasticizers, which contribute to the flexibility and durability of the film …
https://www.sciencedirect.com/science/article/pii/S230750231630056X
Topical application therefore shows greater bioavailability and faster onset of action compared to oral route. Topical delivery of drug through nail is also known as Transungual Drug Delivery. System where ‘trans’ means through and ‘ungual’means nails. 5. Factors affecting diffusion of drugs through nails …Author: Pradnya Palekar Shanbhag, Urvi Jani
http://www.sgrrits.org/pdf/e-content/pharma/Nail-Lacquers.pdf
NAIL LACQUERS (TRANSUNGAL) AS A DRUG DELIVERY SYSTEM INTRODUCTION Nails are the hard and durable epidermal. Nail plate is responsible for the penetration of the drug across it. There are number of formulations with antifungal agents viz. gels, creams and oral antifungals for the treatment of transungual infections.
http://www.japsonline.com/admin/php/uploads/368_pdf.pdf
The nail lacquer is a new drug delivery system in treatment of nail infections. The major hurdle associated with developing nail lacquers treatment for nail disorders is to deliver the active (antifungal) therapeutically effective concentrations to the site of infection, which is often under nail.Author: Vivek B Rajendra, Anjana Baro, Abha Kumari, Dinesh L Dhamecha, Swaroop R Lahoti, Santosh D Shelke
https://www.slideshare.net/konathamtejakumarred/drug-delivery-through-nails
Dec 12, 2016 · As it is hard enough the penetration becomes difficult . For the successful treatment of nail disease the applied active drug must permeate through the dense keratinized nail plate and reach deeper layers, the nail bed and the nail matrix. most commonly topical drug are used to penetrates across it. These diseases can be cured by achieving desired therapeutic concentration of drug by nail drug delivery system. Various topical therapies for nail disorders…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151314/
Drug delivery systems such as nanoparticles, liposomes, microemulsions, and polymeric implantable devices are emerging as one of the viable alternatives that have been demonstrated to deliver therapeutic concentrations of various potent chemopreventives such as curcumin, ellagic acid, green tea polyphenols, and resveratrol into the systemic ...Author: Shyam S. Bansal, Mehak Goel, Farrukh Aqil, Manicka V. Vadhanam, Ramesh C. Gupta
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