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https://www.ncbi.nlm.nih.gov/pubmed/23770008
Sep 28, 2013 · The technology used to create nab-paclitaxel utilizes albumin to deliver paclitaxel, resulting in an advantageous pharmacokinetic (PK) profile. This review discusses the proposed mechanism of delivery of nab-paclitaxel, including an examination into a hypothesized greater ability to leverage albumin-based transport relative to sb-paclitaxel.Author: Denise A. Yardley
https://www.sciencedirect.com/science/article/pii/S0168365913003337
Thus, nab-paclitaxel appears to interact with tumors in a number of interesting, but not fully understood, ways. Continued preclinical and clinical research across a range of tumor types is warranted to answer the questions that remain on the mechanisms of delivery and antitumor activity of nab-paclitaxel.Author: Denise A. Yardley
https://www.researchgate.net/publication/239072046_Nab-Paclitaxel_mechanisms_of_action_and_delivery
Among them nab-paclitaxel appears promising because it combines cytotoxic therapy with targeted delivery. Nab-paclitaxel is a colloidal suspension of nanoparticles homogenised in human serum ...Author: Denise Yardley
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284885/
nab-Paclitaxel is a solvent-free, albumin-bound nanoparticle formulation of paclitaxel that takes advantage of the increased delivery of albumin to tumors through receptor-mediated transport called transcytosis. nab-Paclitaxel binds to gp60, the albumin receptor on endothelial cells, which in turn activates caveolin-1 and the formation of ...Author: J Iglesias
https://www.dovepress.com/nanoparticle-albumin-bound-nab-paclitaxel-for-the-treatment-of-pancrea-peer-reviewed-fulltext-article-GICTT
Nanoparticle albumin-bound (nab)-paclitaxel also increases gemcitabine levels inside the tumor cells by inhibiting cytidine deaminase, the enzyme that degrades gemcitabine. This review focuses on proposed mechanisms of efficacy of nab-paclitaxel in pancreatic cancer and discusses the preclinical and clinical studies of relevance.
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2282
Jun 23, 2009 · nab-Paclitaxel is a solvent-free, albumin-bound nanoparticle formulation of paclitaxel that takes advantage of the increased delivery of albumin to tumors through receptor-mediated transport called transcytosis.nab-Paclitaxel binds to gp60, the albumin receptor on endothelial cells, which in turn activates caveolin-1 and the formation of caveolae.. Caveolae transport the albumin–paclitaxel ...Author: J Iglesias
https://www.researchgate.net/publication/261255311_Nab-Paclitaxel_for_Metastatic_Pancreatic_Cancer_Clinical_Outcomes_and_Potential_Mechanisms_of_Action
Nab-Paclitaxel for Metastatic Pancreatic Cancer: Clinical Outcomes and Potential Mechanisms of Action. ... The study goal was to examine the relationship between nab-paclitaxel delivery and SPARC ...
http://www.pdr.net/drug-summary/Abraxane-paclitaxel-protein-bound-663
Nanoparticle albumin-bound (NAB) paclitaxel utilities a unique mechanism for transportation of paclitaxel into the cells. NAB paclitaxel utilizes a receptor-mediated (gp60) pathway on microvessel endothelial cells to transport the albumin-paclitaxel complex out of the blood stream and into the tumor interstitium.
https://en.wikipedia.org/wiki/Paclitaxel
Albumin-bound paclitaxel (trade name Abraxane, also called nab-paclitaxel) is an alternative formulation where paclitaxel is bound to albumin nanoparticles. Much of the clinical toxicity of paclitaxel is associated with the solvent Cremophor EL in which it is dissolved for delivery.Formula: C₄₇H₅₁NO₁₄
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