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http://www.misoprostol.org/dosage-guidelines/
10 rows · 13-24 wks: 400mcg vaginally/sublingually/buccal 3-hrly. 25-26 wks: 200mcg ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760893/
Misoprostol is a proven induction agent in the second trimester for termination of pregnancy or fetal death. One regimen is 400 µg vaginally every 6 hours up to 48 hours. For cervical ripening and induction of labor for a viable fetus, 25 µg of vaginal misoprostol every 4 to 6 hours is recommended.Cited by: 102
https://pubmed.ncbi.nlm.nih.gov/9119097/
All women were hospitalized and administered 600 mg of mifepristone, followed 24 hours later by 400 mcg of misoprostol every 6 hours until fetal expulsion. Medical reasons for pregnancy termination included fetal morphological abnormalities (34.9%), intrauterine death (26.4%), chromosome anomalies (16.9%), and maternal indications (19%).Cited by: 61
https://www.ncbi.nlm.nih.gov/pubmed/8724617
Women in group 1 were given 400 mcg of oral misoprostol every 3 hours up to five doses, while patients in group 2 were given 1 mg of vaginal gemeprost every 6 hours up to four doses. There was no significant difference in the median induction-abortion intervals or the incidence of side effects between the two groups of patients. The authors therefore conclude that misoprostol is as effective as gemeprost …Cited by: 70
http://www.misoprostol.org/intrauterine-fetal-death/
Vaginal misoprostol 200 mcg every 6 to 12 hours for a total of 4 doses; If the first dose does not lead to effective contractions the subsequent dose could be doubled to 400 mcg. The maximum daily dosing should not exceed 1600 mcg; B. IUFD from 18 to 26 weeks. Vaginal misoprostol 100 mcg every 6 to12 hours for a total of 4 doses.
http://anmc.org/wp-content/uploads/ANMCWomensHealthGuidelines3-13-2018/31-45/Misoprostol%20Cervical%20Ripening%20and%20Labor%20Induction.pdf
Mar 13, 2018 · may give 100-200 mcg vaginally per provider orders every 4 hours until an active labor pattern has been established. Misoprostol has been given orally in doses of 100-200 mcg every four hours although the induction may be prolonged. For gestational age of < 28 weeks dosage of 200-400 mcg vaginally every 4-12 hours is permissible.
https://clinicaltrials.gov/ct2/show/NCT02159911
Jun 10, 2014 · Jun 10, 2014 · Other Name: ( Cytotec*) 400 mcg misoprostol. Misoprostol administered orally one hour before surgery. Drug: Misoprostol administered orally one hour before surgery. Closed and numbered envelopes, containing a capsule with either 200mcg or 400mcg of misoprostol were randomly distributed to the patients.
https://www.drugs.com/dosage/misoprostol.html
Nov 23, 2020 · 25 mcg vaginally every 3 to 6 hours-Some patients may require doses of 50 mcg every 6 hours Comments:-The manufacturer states that use outside of the approved indication should be reserved for hospital use only.-Some experts state that this drug is a more efficient method of labor (compared to oxytocin) in patients before 28 weeks' gestation.
https://treehozz.com/how-long-does-it-take-for-misoprostol-to-soften-cervix
Mar 02, 2020 · One regimen is 400 µg vaginally every 6 hours up to 48 hours. For cervical ripening and induction of labor for a viable fetus, 25 µg of vaginal misoprostol every 4 to 6 hours is recommended. Click to read full answer. Also to know is, how long does it take for misoprostol to take effect?
https://pubmed.ncbi.nlm.nih.gov/11759980/
Conclusion: The effectiveness in terms of treatment interval from induction to vaginal delivery were comparable between the two groups, but administration of misoprostol every 6 hours was found to have a slightly shorter interval, although it did not reach statistical significance. No serious maternal and neonatal complication was demonstrated in both groups.
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