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http://www.misoprostol.org/dosage-guidelines/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760893/
Misoprostol is a proven induction agent in the second trimester for termination of pregnancy or fetal death. One regimen is 400 µg vaginally every 6 hours up to 48 hours. For cervical ripening and induction of labor for a viable fetus, 25 µg of vaginal …
https://www.drugs.com/dosage/misoprostol.html
25 mcg vaginally every 3 to 6 hours-Some patients may require doses of 50 mcg every 6 hours Comments:-The manufacturer states that use outside of the approved indication should be reserved for hospital use only.-Some experts state that this drug is a more efficient method of labor (compared to oxytocin) in patients before 28 weeks' gestation.
http://www.misoprostol.org/intrauterine-fetal-death/
Vaginal misoprostol 200 mcg every 6 to 12 hours for a total of 4 doses; If the first dose does not lead to effective contractions the subsequent dose could be doubled to 400 mcg. The maximum daily dosing should not exceed 1600 mcg; B. IUFD from 18 to 26 weeks. Vaginal misoprostol 100 mcg every 6 to12 hours for a total of 4 doses.
https://pubmed.ncbi.nlm.nih.gov/9119097/
All women were hospitalized and administered 600 mg of mifepristone, followed 24 hours later by 400 mcg of misoprostol every 6 hours until fetal expulsion. Medical reasons for pregnancy termination included fetal morphological abnormalities (34.9%), intrauterine death (26.4%), chromosome anomalies (16.9%), and maternal indications (19%).
https://www.obgproject.com/2021/11/03/induction-of-labor-indications-and-management/
Misoprostol 400 to 600 mcg vaginally every 4 to 6 hours >28 weeks. Standard obstetric protocol for labor induction; Prior uterine scar <28 weeks: Lower doses of Misoprostol (200 mcg) may be preferred >28 weeks: Foley for cervical ripening; Prior classical incision. Limited data to guide clinical practice; SFP 2013 <28 weeks
https://pubmed.ncbi.nlm.nih.gov/11759980/
Objective: To compare the effectiveness and safety between 50 mcg oral misoprostol every 4 hours and 6 hours for labor induction. Design: A prospective randomized controlled trial. Setting: Department of Obstetrics & Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Subjects: Eighty nine pregnant women of at least 34 weeks' gestation with …
http://anmc.org/wp-content/uploads/ANMCWomensHealthGuidelines3-13-2018/31-45/Misoprostol%20Cervical%20Ripening%20and%20Labor%20Induction.pdf
may give 100-200 mcg vaginally per provider orders every 4 hours until an active labor pattern has been established. Misoprostol has been given orally in doses of 100-200 mcg every four hours although the induction may be prolonged. For gestational age of < 28 weeks dosage of 200-400 mcg vaginally every 4-12 hours is permissible.
http://anmc.org/wp-content/uploads/guidelines04182018/2ndtrimmisocesarean.pdf
6. The same dose of misoprostol, 400 mcg, may be administered vaginally again in 6 hours, and every 6 hours, up to 6 doses. Delivery should be expected within 24 hours in up to 90% of patients. The remaining women should be expected to deliver within 36-48 hours without addition of a second agent. Amniotomy may be
https://clinicaltrials.gov/ct2/show/NCT02159911
Other Name: ( Cytotec*) 400 mcg misoprostol. Misoprostol administered orally one hour before surgery. Drug: Misoprostol administered orally one hour before surgery. Closed and numbered envelopes, containing a capsule with either 200mcg or 400mcg of misoprostol were randomly distributed to the patients.
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