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https://pubmed.ncbi.nlm.nih.gov/9640281/
To avoid this complication, metformin must be withheld after the administration of the contrast agent for 48 hours, during which the contrast-induced renal failure becomes clinically apparent. If renal function is normal at 48 hours, the metformin can be restarted.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537815/
Guidelines from the Canadian Association of Radiologists 2 state that patients taking metformin who have an eGFR of less than 60 mL/min should restart the drug no sooner than 48 hours after contrast administration and only if renal function remains stable (< 25% increase in creatinine above baseline).
http://www.med.umich.edu/1libr/radiology/ContrastMetformin.pdf
Metformin should be stopped at the time of your test and for at least 48 hours after your test, because of the risk of lactic acidosis in the rare event that a serious change in your kidney function were to occur.
https://www.healthtap.com/questions/382737-why-should-you-not-take-metformin-for-48-hours-after-having-a-ct-scan-had-ct-scan-for-pain-in-abdome/
The : The combination of metformin and ct contrast (the dye that is injected) can be hard on the kidneys, and can cause a condition called "lactic acidosis " where the blood becomes too acidotic and can also damage the kidneys. Waiting 48 hours has been shown to be a safe time period after receiving ct contrast to resume your metformin.
https://www.triadradiology.com/metformin-and-iodinated-contrast/
Patients with any of these risk factors for lactic acidosis must have their metformin-containing medications withheld for 48 hours after receiving contrast, and then restarted once renal function has been re-evaluated and found to be normal.
https://www.bmj.com/rapid-response/2011/10/29/metformin-and-x-ray-contrast-medium
states that metformin should be stopped 48 hours prior to angiography and reinstated 48 hours after in order to minimise potential renal risk. This contradicts the current guidelines published by the Royal College of Radiologists on the use of iodinated contrast medium (2) which state that in patients with normal renal function metformin be stopped …
https://www.cmaj.ca/content/185/1/E78
Restarting metformin depends on renal function and the volume of contrast used Guidelines from the Canadian Association of Radiologists 2 state that patients taking metformin who have an eGFR of less than 60 mL/min should restart the drug no sooner than 48 hours after contrast administration and only if renal function remains stable (< 25% increase in creatinine …
https://www.uclahealth.org/radiology/workfiles/referralforms/Metformin-Protocol.pdf
for CT Studies with IV Radiographic Contrast Media 1. Metformin medications are generally used for patients with diabetes, pre-diabetes, and indications such as polycystic ovarian syndrome (PCOS). 2. Metformin medications should be stopped at the time of or prior to CT studies with IV Contrast, AND withheld for 48 hours after the procedure. 3.
https://cdn.mdedge.com/files/s3fs-public/JHMVol16No8_Cohen10740818e.PDF
(eGFR ≥30 mL/min/1.73m 2) receiving IV contrast. They advise holding metformin for 48 hours in patients with renal insuffi-ciency (eGFR <30 mL/min/1.73m2) or those undergoing IA catheter studies that might result in renal artery emboli.18 Finally, continuing metformin maintains steady blood glucose control. The practice of replacing metformin with
http://www.sfrnet.org/data/upload/files/a7e7222e420ac736c1256b6c0044cb07/contrast%20media%20diabetes.pdf
in 48 hours. Metformin is contraindicated in cases of renal insufficiency. Accumulation of the drug can induce lactic acidosis when contrast medium induced renal failure happens (in the 48 hours following the injection). The therapy should be discontinued for 48 hours from the time of iodinated contrast medium administration.
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