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https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801423
The multistage delivery nanoparticle (denoted as MDNP) has a core–shell structure, in which the core is a cationic polyplex made from CRISPR/dCas9 plasmid DNA (pDNA) and phenylboronic acid (PBA)‐modified low molecular weight polyethyleneimine (PEI–PBA), whereas the shell is formed by 2,3‐dimethylmaleic anhydride (DMMA)‐modified poly(ethylene glycol)‐b‐polylysine (mPEG 113 …Author: Qi Liu, Kai Zhao, Chun Wang, Zhanzhan Zhang, Chunxiong Zheng, Yu Zhao, Yadan Zheng, Chaoyong Liu, Yi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327631/
Jan 07, 2017 · Multistage drug delivery systems (Ms-DDS), also referred to as stimuli-responsive or activatable systems, show different behaviors during systemic circulation and in the tumor microenvironment. Ms-DDS have been developed in the 1970s when the first thermo-sensitive liposome for accelerated and quick release of drugs in the tumor was designed 8.Author: Binlong Chen, Wenbing Dai, Bing He, Hua Zhang, Xueqing Wang, Yiguang Wang, Qiang Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325604/
Jan 09, 2019 · The multistage delivery nanoparticle (denoted as MDNP) has a core–shell structure, in which the core is a cationic polyplex made from CRISPR/dCas9 plasmid DNA (pDNA) and phenylboronic acid (PBA)‐modified low molecular weight polyethyleneimine (PEI–PBA), whereas the shell is formed by 2,3‐dimethylmaleic anhydride (DMMA)‐modified poly(ethylene glycol)‐b‐polylysine (mPEG 113 …Author: Qi Liu, Kai Zhao, Chun Wang, Zhanzhan Zhang, Chunxiong Zheng, Yu Zhao, Yadan Zheng, Chaoyong Liu, Yi...
https://www.pnas.org/content/108/6/2426
Feb 08, 2011 · Multistage nanoparticle systems provide additional tunability in the spatial control of delivery to solid tumors. Because of the multiple physiological barriers that a therapeutic agent must encounter, a multistage nanoparticle system can enhance penetration by changing its size, charge, shape, flexibility, and/or surface coating to suit the transport across each barrier.Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.sciencedirect.com/science/article/pii/S0304383512004387
Central to the multistage drug delivery strategy is the ability of the carrier to release, site-specifically and in a controlled fashion, a powerful payload of chemotherapeutics following …Author: Elvin Blanco, Takafumi Sangai, Angela Hsiao, Silvia Ferrati, Litao Bai, Xuewu Liu, Funda Meric-Berns...
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201807294
In this study, a multistage delivery system capable of reversing hypoxia is demonstrated. Unlike previous strategies that only expect to affect the peripheral tumor tissue, the size‐shrinkable system allows those deeply located hypoxia regions to be treated.Author: Donglin Xia, Donglin Xia, Peipei Xu, Xingyu Luo, Jianfeng Zhu, Haiying Gu, Da Huo, Yong Hu
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