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https://www.sciencedirect.com/science/article/pii/S0169409X12002918
5.3. Transduction function and cytosolic delivery. A new approach in intracellular drug delivery has recently emerged, based on the modification of drugs and drug carriers with certain proteins and peptides demonstrating a unique ability to penetrate into cells (“protein transduction” phenomenon).
https://www.researchgate.net/publication/257525268_Multifunctional_nanocarriers_and_intracellular_drug_delivery
Multifunctional nanocarriers and intracellular drug delivery Article in Current Opinion in Solid State and Materials Science 16(6):269–275 · December 2012 with 50 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S1359028612000393
1. Introduction: multifunctional nanocarriers and earlier developments. The advantages of nanocarriers for the delivery of therapeutic and diagnostic agents in vivo have now been well established with an increasing number of formulations reaching clinics. Nanocarriers offer solutions that overcome some of the limitations of conventional drug delivery systems such as poor aqueous solubility ...Author: Rupa R. Sawant, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pubmed/26544061
Dec 07, 2015 · Design of Multifunctional Liposomal Nanocarriers for Folate Receptor-Specific Intracellular Drug Delivery. ... As a novel carrier for folate receptor (FR)-targeted intracellular delivery, we designed two types of targetable liposomal systems using Pep-1 peptide (Pep1) and folic acid as a cell-penetrating peptide (CPP) and target molecule ...Author: Kang Mh, Yoo Hj, Kwon Yh, Yoon Hy, Lee Sg, Kim, Yeom Dw, Kang Mj, Choi Yw
http://www.thno.org/v10p4557.htm
For example, nanocarriers responding to both intracellular pH and GSH have been developed for promoted intracellular drug delivery . In another study, the developed platinum drug delivery nanocarriers could response to intracellular GSH for disassociation, and response to …
https://www.nature.com/articles/nrd4333
Oct 07, 2014 · The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in vivo effectiveness of drugs is now well established. The development of multifunctional and stimulus ...Author: Vladimir P. Torchilin, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930408/
Jan 01, 2020 · In this review, we retrospectively summarized the recent advances of nanocarriers for targeted drug delivery in osteosarcoma. We discuss the commonly used types of drug delivery nanoparticles, controlled drug release upon different stimuli, and nanocarriers modification strategies for targeted drug delivery.Author: Shang-Yu Wang, Hong-Zhi Hu, Xiang-Cheng Qing, Zhi-Cai Zhang, Zeng-Wu Shao
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00399
Fol-Pep1 and Pep-1 cytotoxicities were negligible up to 25 μM in FR-positive and FR-negative cells. Empty cF-P-L and dF/P-L were nontoxic at the concentration used. The optimized dF 3 /P 2 (450/90) system carrying 450 PEG 3400-linked folate and 90 PEG 2000-linked Pep1 molecules could be a good candidate for FR-specific intracellular drug delivery.Author: Kang Mh, Yoo Hj, Kwon Yh, Yoon Hy, Lee Sg, Kim, Yeom Dw, Kang Mj, Choi Yw
https://www.researchgate.net/publication/296834764_Multifunctional_nanocarriers
This paper considers current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity ...
https://pubs.acs.org/doi/10.1021/bm401342t
Nov 12, 2013 · The decoration of FA results in an enhanced cellular uptake and improved drug efficacy toward FA-receptor positive HeLa cancer cells in vitro. As a proof-of-concept, this work provides a facile approach to the design of extracellularly activatable nanocarriers for tumor-targeted and programmed intracellular drug delivery.Author: Nijia Song, Mingming Ding, Zhicheng Pan, Jiehua Li, Lijuan Zhou, Hong Tan, Qiang Fu
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